1-Bromonaphthalen-2-amine

Base Information

• Chemical Name: 1-Bromonaphthalen-2-amine
• CAS No.: 20191-75-7
• Molecular Formula: C10H8 Br N
• Molecular Weight: 222.084
• DSSTox Substance ID: DTXSID90446473
• Nikkaji Number: J661.356J
• Wikidata: Q82265116
• Mol file: 20191-75-7.mol

Synonyms:1-bromonaphthalen-2-amine;20191-75-7;2-amino-1-bromonaphthalene;1-Bromo-2-naphthylamine;MFCD00086888;1-bromo-2-aminonaphthalene;SCHEMBL1913838;DTXSID90446473;WENXBAFANCRIGK-UHFFFAOYSA-N;AKOS016368756;MB00604;NS-02705;CS-0135297;FT-0715550;EN300-146502;F13243;A852909

Chemical Property of 1-Bromonaphthalen-2-amine

Chemical Property:

• Vapor Pressure: 6.12E-05mmHg at 25°C
• Melting Point: 63-64 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 345.5oC at 760 mmHg
• PKA: 1.51±0.10(Predicted)
• Flash Point: 162.8oC
• PSA: 26.02000
• Density: 1.563g/cm3
• LogP: 3.76570
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 220.98401
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99%+ ^*data from raw suppliers

1-bromonaphthalen-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2Br)N

Technology Process of 1-Bromonaphthalen-2-amine

There total 21 articles about 1-Bromonaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

naphthalen-2-ylamine (91-59-8) → 1-bromo-2-naphthylamine (20191-75-7)

Guidance literature:

With N-Bromosuccinimide; sulfonic acid functionalized silica; In diethyl ether; acetonitrile; at 20 ℃; for 0.0166667h;

DOI:10.1016/j.tetlet.2006.10.029

Reference yield:

2-naphthylamine hydrochloride (612-52-2) → 1-bromo-2-naphthylamine (20191-75-7)

Guidance literature:

With N-Bromosuccinimide; toluene-4-sulfonic acid; In tetrahydrofuran; at 0 - 23 ℃;

DOI:10.1021/ja075398e

Reference yield:

2-acetylaminonaphthalene (581-97-5) → 1-bromo-2-naphthylamine (20191-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / CCl₄

2: hydrolysis

With bromine; In tetrachloromethane;

upstream raw materials:

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

naphthalen-2-ylamine

N-(2-naphthyl)-p-toluenesulphonamide

3-amino-4-bromo-2-naphthoic acid

Downstream raw materials:

2-(1-bromo-[2]naphthylamino)-4-chloro-benzoic acid

1-bromo-2-iodonaphthalene

1-bromo-2-naphthalenyl-2-carbonitrile

N-(1-bromonaphthalen-2-yl)benzamide

Refernces

• 1、 Jin, Wei,Trzupek, John D.,Rayl, Thomas J.,Broward, Melinda A.,Vielhauer, George A.,Weir, Scott J.,Hwang, Inkyu,Boger, Dale L.. "A unique class of duocarmycin and CC-1065 analogues subject to reductive activation". . p. 15391 - 15397. Retrieved 2007.
• 2、 -. "Compound for organic photoelectric device Composition for organic photoelectric device, organic photoelectric device, and display device". Paragraph 0201-0205. . Retrieved 2021/10/13.