2-Naphthalenamine, hydrochloride

Base Information

• Chemical Name: 2-Naphthalenamine, hydrochloride
• CAS No.: 612-52-2
• Molecular Formula: C10H9 N . Cl H
• Molecular Weight: 179.649
• European Community (EC) Number: 210-313-6
• DSSTox Substance ID: DTXSID20976713
• NSC Number: 4153
• Mol file: 612-52-2.mol

Synonyms:2-naphthylamine hydrochloride;612-52-2;2-Naphthalenamine, hydrochloride;2-NAPHTHYLAMINE, HYDROCHLORIDE;SCHEMBL1467866;DTXSID20976713;NSC4153;.beta.-Naphthylamine hydrochloride;NSC-4153;AKOS024438438;Naphthalen-2-amine--hydrogen chloride (1/1)

Chemical Property of 2-Naphthalenamine, hydrochloride

Chemical Property:

• Vapor Pressure: 0.000722mmHg at 25°C
• Melting Point: <100 °C
• Boiling Point: 307.5°C at 760 mmHg
• Flash Point: 157.1°C
• PSA: 26.02000
• Density: 1.41 g/cm3
• LogP: 3.80520
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 179.0501770
• Heavy Atom Count: 12
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

2-NaphthylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)N.Cl
• Uses: 2-Naphthylamine Hydrochloride is listed as a known human carcinogen used in the manufacturing of dyes and as antioxidant in rubber.

Technology Process of 2-Naphthalenamine, hydrochloride

There total 6 articles about 2-Naphthalenamine, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

naphthalen-2-yl-carbamic acid tert-butyl ester (454713-45-2) → 2-naphthylamine hydrochloride (612-52-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 1h;

DOI:10.1021/ja075398e

Reference yield:

naphthalen-2-ylamine (91-59-8) → 2-naphthylamine hydrochloride (612-52-2)

Guidance literature:

With hydrogenchloride; In acetic acid; at 0.5 ℃;

Reference yield:

naphthalene-2-carboxylate (93-09-4) → 2-naphthylamine hydrochloride (612-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 24 h / Molecular sieve; Heating / reflux

2: hydrogenchloride / ethyl acetate / 1 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethyl acetate; toluene;

upstream raw materials:

[1]naphthylamine; compound with 2-chloro-1.3.5-trinitro-benzene

N-<1-(p-aminophenyl)-3-(9-anthryl)-propen-1-ylidene>-2-naphthylamine

naphthalen-2-ylamine

naphthalen-2-yl-carbamic acid tert-butyl ester

Downstream raw materials:

N,N-dimethyl-1-naphthalenamine

4-methyl-5,6-benzoquinoline

N,N-diethyl-1-naphthylamine

4-(4-amino-naphthalen-1-ylazo)-benzenesulfonic acid

Refernces

• 1、 -. "CBI DERIVATIVES SUBJECT TO REDUCTIVE ACTIVATION". Page/Page column 36. . Retrieved 2009/06/27.
• 2、 Koslov, N. S.,Shmanai, G. S.,Gladchenko, L. F.. "ANTHRACENE DERIVATIVES OF BENZOQUINOLINE. SYNTHESIS, SPECTRA, AND LUMINESCENCE". . p. 1268 - 1272. Retrieved 2007/10/02.