Technology Process of 2,4-Imidazolidinedione,
5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-5-phenyl-, (5S)-
There total 8 articles about 2,4-Imidazolidinedione,
5-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-5-phenyl-, (5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
isocyanate de chlorosulfonyle; (S)-2-amino-3-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-N-methyl-2-phenylpropionamide;
In
dichloromethane;
at 0 ℃;
for 3h;
With
hydrogenchloride;
In
1,4-dioxane;
DOI:10.1021/ol030104p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 98.7 percent / chiral oxazaborolidine; BH3*SMe2 / CH2Cl2; toluene / -20 °C
2.1: Heating
2.2: hydrogen bromide
3.1: LDA*THF / tetrahydrofuran; cyclohexane / 0.83 h / -78 °C
3.2: 55 percent / tetrahydrofuran; cyclohexane / 2 h / -78 °C
4.1: 94 percent / hydrochloric acid / methanol / 87 °C
5.1: CH2Cl2 / 3 h / 0 °C
5.2: 71 percent / hydrochloric acid / dioxane
With
hydrogenchloride; dimethylsulfide borane complex; chiral oxazaborolidine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane; toluene;
DOI:10.1021/ol030104p
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Heating
1.2: hydrogen bromide
2.1: LDA*THF / tetrahydrofuran; cyclohexane / 0.83 h / -78 °C
2.2: 55 percent / tetrahydrofuran; cyclohexane / 2 h / -78 °C
3.1: 94 percent / hydrochloric acid / methanol / 87 °C
4.1: CH2Cl2 / 3 h / 0 °C
4.2: 71 percent / hydrochloric acid / dioxane
With
hydrogenchloride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane;
DOI:10.1021/ol030104p