2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-
• CAS No.: 350490-15-2
• Molecular Formula: C13H15BrO2
• Molecular Weight: 283.165
• Mol file: 350490-15-2.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)-

There total 12 articles about 2-Propenoic acid, 3-(4-bromophenyl)-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

tert-butyl diethylphosphonoacetate (27784-76-5) + 4-bromo-benzaldehyde (1122-91-4) → tert-butyl (E)-3-(4-bromophenyl)prop-2-enoate (350490-15-2)

Guidance literature:

tert-butyl diethylphosphonoacetate; With sodium hydride; In tetrahydrofuran; at 20 - 35 ℃; for 1h;

4-bromo-benzaldehyde; In tetrahydrofuran; at 20 - 35 ℃; for 1.5h;

Reference yield: 81.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + (4-bromophenyl)hydrazine (589-21-9) → tert-butyl (E)-3-(4-bromophenyl)prop-2-enoate (350490-15-2)

Guidance literature:

With Bathocuproine; palladium diacetate; acetic acid; In methanol; chlorobenzene; at 40 ℃; for 2h; under 760.051 Torr; chemoselective reaction;

DOI:10.1021/ol202862t

Reference yield: 68.0%

acetic acid tert-butyl ester (540-88-5) + 4-bromo-benzaldehyde (1122-91-4) → tert-butyl (E)-3-(4-bromophenyl)prop-2-enoate (350490-15-2)

Guidance literature:

With N,N-Dimethyltrimethylsilylamine; tetramethylammonium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c2cc35701a

upstream raw materials:

(tert-Butoxycarbonylmethylene)triphenylphosphorane

4-bromo-benzaldehyde

tert-butyl diethylphosphonoacetate

4-bromocinnamoyl chloride

Downstream raw materials:

tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)-amino]-3-(4'-bromophenyl)propanoate

C₂₈H₃₂BrNO₂

trans-2-(4-bromophenyl)cyclopropanecarboxylic acid

tert-butyl 2-(4-bromophenyl)cyclopropanecarboxylate

Refernces

• 1、 -. "AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF". Paragraph 0540-0542. . Retrieved 2020/01/31.
• 2、 -. "PROCESS FOR THE PREPARATION OF (E)-3-(4-((E)-2-(2-CHLORO-4-FLUOROPHENYL)-1-(1H-INDAZOL-5-YL)BUT-1-EN-1-YL)PHENYL)ACRYLIC ACID". Page/Page column 30; 31. . Retrieved 2017/05/07.