1H-Imidazole, 1-methyl-2-(trimethylsilyl)-

Base Information

• Chemical Name: 1H-Imidazole, 1-methyl-2-(trimethylsilyl)-
• CAS No.: 35342-89-3
• Molecular Formula: C7H14N2Si
• Molecular Weight: 154.287
• Hs Code.: 2933290090
• NSC Number: 603435
• DSSTox Substance ID: DTXSID00326595
• Nikkaji Number: J3.008.108K
• Wikidata: Q82087679
• Mol file: 35342-89-3.mol

Synonyms:1H-Imidazole, 1-methyl-2-(trimethylsilyl)-;35342-89-3;trimethyl-(1-methylimidazol-2-yl)silane;NSC603435;SCHEMBL6345915;DTXSID00326595;1-methyl-2-trimethylsilylimid-azole;AKOS006317448;NSC-603435;2-(Trimethylsilyl)-1-methyl-1H-imidazole

Chemical Property of 1H-Imidazole, 1-methyl-2-(trimethylsilyl)-

Chemical Property:

• PSA: 17.82000
• LogP: 0.96530
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 154.092624989
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

1-METHYL-2-(TRIMETHYLSILYL)-1H-IMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C=CN=C1[Si](C)(C)C

Technology Process of 1H-Imidazole, 1-methyl-2-(trimethylsilyl)-

There total 3 articles about 1H-Imidazole, 1-methyl-2-(trimethylsilyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

chloro-trimethyl-silane (75-77-4) + C16H33N4P → 1-methyl-2-(trimethylsilyl)-1H-imidazole (35342-89-3)

Guidance literature:

In diethyl ether; at -100 - -95 ℃; Inert atmosphere;

DOI:10.1021/jo101177h

Reference yield: 54.0%

1-methyl-1H-imidazole (616-47-7) + chloro-trimethyl-silane (75-77-4) → 1-methyl-2-(trimethylsilyl)-1H-imidazole (35342-89-3)

Guidance literature:

1-methyl-1H-imidazole; With n-butyllithium; In tetrahydrofuran; at -78 - -20 ℃; for 1.16667h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; at -78 - -70 ℃;

DOI:10.1016/j.tetlet.2011.08.010

Reference yield:

→ 1-methyl-2-(trimethylsilyl)-1H-imidazole (35342-89-3)

Guidance literature:

1-Methylimidazol 1)n-BuLi 2)Me3SiCl;

upstream raw materials:

1-methyl-1H-imidazole

chloro-trimethyl-silane

Downstream raw materials:

ethyl 1-methyl-1H-imidazole-2-carboxylate

isopropyl 1-methylimidazole-2-carboxylate

benzyl 1-methylimidazole-2-carboxylate

methyl 1-methyl-1H-imidazole-2-carboxylate

Refernces

• 1、 Marchenko, Anatolii P.,Koidan, Heorgii N.,Huryeva, Anastasiya N.,Zarudnitskii, Evgeniy V.,Yurchenko, Aleksandr A.,Kostyuk, Aleksandr N.. "N-phosphorylated imidazolium salts as precursors to 2- and 5-phosphorylated imidazoles and new imidazol-2-ylidenes featuring the PNCN unit". supporting information; experimental part. p. 7141 - 7145. Retrieved 2010/12/29.