(4-Benzylphenyl)methanol

Base Information

• Chemical Name: (4-Benzylphenyl)methanol
• CAS No.: 35714-20-6
• Molecular Formula: C14H14O
• Molecular Weight: 198.265
• Hs Code.: 2906299090
• DSSTox Substance ID: DTXSID101304985
• Nikkaji Number: J102.221K
• Mol file: 35714-20-6.mol

Synonyms:(4-Benzylphenyl)methanol;35714-20-6;4-(phenylmethyl)benzenemethanol;4-benzylbenzyl alcohol;Benzenemethanol, 4-(phenylmethyl)-;p-Hydroxymethyldiphenylmethane;4-benzylbenzylalcohol;p-benzylbenzyl alcohol;4-(benzyl)benzyl alcohol;(4-benzylphenyl)-methanol;(4-Benzylphenyl)methanol #;SCHEMBL2288601;BENZYL ALCOHOL IMPURITY K;DTXSID101304985;AKOS013800965;SS-4832;4-(PHENYL METHYL)-BENZENE METHANOL;CS-0437649;EN300-126543;Z1233157998

Chemical Property of (4-Benzylphenyl)methanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.76970
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 198.104465066
• Heavy Atom Count: 15
• Complexity: 164

Purity/Quality:

99%min ^*data from raw suppliers

(4-benzylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC2=CC=C(C=C2)CO

Technology Process of (4-Benzylphenyl)methanol

There total 16 articles about (4-Benzylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Benzylbenzoic acid (620-86-0) → 4-benzylbenzyl alcohol (35714-20-6)

Guidance literature:

4-Benzylbenzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; diethyl ether; at 4 - 20 ℃; for 0.5h;

Reference yield: 92.0%

methyl 4-benzylbenzoate (23450-30-8) → 4-benzylbenzyl alcohol (35714-20-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 77.0%

4-bromobenzenemethanol (873-75-6) + benzyl chloride (100-44-7) → 4-benzylbenzyl alcohol (35714-20-6)

Guidance literature:

benzyl chloride; With indium(III) chloride; magnesium; lithium chloride; In tetrahydrofuran; at 25 ℃; for 2h; Schlenk technique; Inert atmosphere;

4-bromobenzenemethanol; With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl acetamide; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201203795

upstream raw materials:

4-benzylbenzyl chloride

2-(4-Benzyl-benzyloxy)-tetrahydro-pyran

4-Benzylbenzoic acid

methanol

Downstream raw materials:

N-(4-Benzylbenzyl)phthalimide

4-benzylbenzaldehyde

2-(2-{2-[2-(4-Benzyl-benzyl)-benzyl]-benzyl}-benzyloxy)-tetrahydro-pyran

2-{2-[2-(4-Benzyl-benzyl)-benzyl]-benzyloxy}-tetrahydro-pyran

Refernces

• 1、 Bernhardt, Sebastian,Shen, Zhi-Liang,Knochel, Paul. "Preparation of functionalized organoindium reagents by means of magnesium insertion into organic halides in the presence of InCl3 at room temperature". supporting information. p. 828 - 833. Retrieved 2013/02/23.
• 2、 -. "MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF". Page/Page column 85. . Retrieved 2008/12/07.