4'-(ETHYLTHIO)ACETOPHENONE

Base Information

• Chemical Name: 4'-(ETHYLTHIO)ACETOPHENONE
• CAS No.: 3585-73-7
• Molecular Formula: C10H12OS
• Molecular Weight: 180.271
• Mol file: 3585-73-7.mol

Synonyms:p-Aethylmercapto-acetophenon;4-Ethylthio-acetophenon;1-(4-Aethylmercapto-phenyl)-aethanon;1-(4-ethylsulfanyl-phenyl)-ethanone;4-(ethylthio)acetophenone;ethyl p-acetylphenyl sulfide;

Chemical Property of 4'-(ETHYLTHIO)ACETOPHENONE

Chemical Property:

• Melting Point: 44.6-45.7 °C
• Boiling Point: 188-192 °C(Press: 29 Torr)
• PSA: 42.37000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 3.00120

Purity/Quality:

95% ^*data from raw suppliers

4''-(Ethylthio)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-(ETHYLTHIO)ACETOPHENONE

There total 7 articles about 4'-(ETHYLTHIO)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

para-bromoacetophenone (99-90-1) + ethanethiol (75-08-1) → 1-[4-(ethylsulfanyl)phenyl]ethan-1-one (3585-73-7)

Guidance literature:

ethanethiol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

para-bromoacetophenone; With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In tetrahydrofuran; toluene; at 40 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201806036

Reference yield: 78.0%

→ 1-[4-(ethylsulfanyl)phenyl]ethan-1-one (3585-73-7)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

Ethyl phenyl sulfide (622-38-8) + acetyl chloride (75-36-5) → 1-[4-(ethylsulfanyl)phenyl]ethan-1-one (3585-73-7)

Guidance literature:

With aluminium trichloride; chloroform;

DOI:10.1021/ja01141a074

upstream raw materials:

Ethyl phenyl sulfide

acetic anhydride

acetyl chloride

4-Iodoacetophenone

Downstream raw materials:

2-[4-(ethanesulfonyl)phenyl]acetic acid

2-(4-(ethylthio)phenyl)acetic acid

4-ethylsulfonylphenacyl bromide

(4-Ethylsulfanyl-phenyl)-oxo-acetic acid

Refernces

• 1、 Scattolin, Thomas,Senol, Erdem,Yin, Guoyin,Guo, Qianqian,Schoenebeck, Franziska. "Site-Selective C?S Bond Formation at C?Br over C?OTf and C?Cl Enabled by an Air-Stable, Easily Recoverable, and Recyclable Palladium(I) Catalyst". supporting information. p. 12425 - 12429. Retrieved 2018/09/18.
• 2、 -. "PYRAZOLONE DERIVATIVES AS NITROXYL DONORS". Page/Page column 185; 215; 307. . Retrieved 2016/01/29.