(2-Fluorophenyl)(phenyl)methanol

Base Information

• Chemical Name: (2-Fluorophenyl)(phenyl)methanol
• CAS No.: 362-54-9
• Molecular Formula: C13H11FO
• Molecular Weight: 202.228
• European Community (EC) Number: 839-458-9
• Nikkaji Number: J1.564.975E
• Mol file: 362-54-9.mol

Synonyms:2-fluorobenzhydrol;(2-fluorophenyl)(phenyl)methanol;MFCD11096237;362-54-9;succinicacid;(2-fluorophenyl)-phenyl-methanol;2-Fluorobenzhydryl alcohol;SCHEMBL477718;(2-fluorophenyl)phenylmethanol;(2-fluorophenyl)-phenylmethanol;HFVMEOPYDLEHBR-UHFFFAOYSA-N;AKOS022302881;CS-0259891;FT-0605143;FT-0605315;EN300-7432544;A808486;Z756122718

Chemical Property of (2-Fluorophenyl)(phenyl)methanol

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 202.079393132
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2F)O

Technology Process of (2-Fluorophenyl)(phenyl)methanol

There total 44 articles about (2-Fluorophenyl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-fluorobenzophenone (342-24-5) → (S)-(2-fluorophenyl)(phenyl)methanol (362-54-9,143880-81-3,146324-43-8)

Guidance literature:

With trans-RuCl₂[(S)-xylbinap][(S)-daipen]; potassium tert-butylate; hydrogen; In isopropyl alcohol; tert-butyl alcohol; at 28 ℃; for 14h; under 6080.41 Torr;

DOI:10.1021/ol9904139

Reference yield: 99.0%

2-Fluorobenzaldehyde (446-52-6) + potassium phenyltrifluoborate → 2-fluorobenzhydrol (362-54-9)

Guidance literature:

With caesium carbonate; bis(η3-allyl-μ-chloropalladium(II)); In water; toluene; at 100 ℃; for 2h;

DOI:10.1021/jo801352h

Reference yield: 99.0%

o-fluorobenzophenone (342-24-5) → (R)-(+)-(2-fluorophenyl)(phenyl)methanol (362-54-9,146324-43-8,143880-81-3) + (S)-(2-fluorophenyl)(phenyl)methanol (362-54-9,143880-81-3,146324-43-8)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₃H₅₃FeN₂O₂PS; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 12h; under 22801.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.8b01276

upstream raw materials:

o-fluorobenzophenone

1,2-bis-(2-fluoro-phenyl)-1,2-diphenyl-ethane-1,2-diol

Phenetole

(2-fluorophenyl)trimethylsilane

Downstream raw materials:

2-[(2-Fluoro-phenyl)-phenyl-methylsulfanyl]-ethylamine; hydrochloride

methyl 2-[(2-fluorophenyl)(phenyl)methoxy]-5-nitrobenzoate

2-methyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole

3-phenyl-1H-indazole

Refernces

• 1、 Chen, Gong,Qiao, Tianjiao,Wang, Yaxin,Zhang, Jian,Zhao, Jianyou. "Tunable System for Electrochemical Reduction of Ketones and Phthalimides". supporting information. p. 3297 - 3302. Retrieved 2021/10/14.
• 2、 -. "Method for synthesizing chiral secondary alcohol compound". Paragraph 0038-0043; 0099-0103. . Retrieved 2021/05/29.