2-Fluorobenzophenone

Base Information

• Chemical Name: 2-Fluorobenzophenone
• CAS No.: 342-24-5
• Molecular Formula: C13H9FO
• Molecular Weight: 200.212
• Hs Code.: 29143990
• European Community (EC) Number: 206-440-1
• NSC Number: 88283
• DSSTox Substance ID: DTXSID3075389
• Nikkaji Number: J193.790A
• Wikidata: Q72479194
• Mol file: 342-24-5.mol

Synonyms:2-Fluorobenzophenone;342-24-5;(2-fluorophenyl)-phenylmethanone;(2-Fluorophenyl)(phenyl)methanone;o-Fluorobenzophenone;fluorobenzophenone;MFCD00000318;C13H9FO;EINECS 206-440-1;NSC88283;2-Fluorobenzophenone, 98%;NCIOpen2_001483;SCHEMBL333008;(2-fluorophenyl)phenylmethanone;DTXSID3075389;DWFDQVMFSLLMPE-UHFFFAOYSA-;(2-fluoro-phenyl)-phenylmethanone;Methanone, (2-fluorophenyl)phenyl-;(2-Fluorophenyl)(phenyl)methanone #;CK2578;NSC 88283;NSC-88283;AKOS009159385;Methanone, (2-fluorophenyl), phenyl-;AC-3639;CS-W015623;FS-4028;SY013693;AM20060285;F0397;FT-0612415;A19708;W-106745

Chemical Property of 2-Fluorobenzophenone

Chemical Property:

• Appearance/Colour: clear slightly yellow to yellow liquid
• Vapor Pressure: 0.88mmHg at 25°C
• Refractive Index: 1.584-1.587
• Boiling Point: 305.6 °C at 760 mmHg
• Flash Point: 135.7 °C
• PSA: 17.07000
• Density: 1.165 g/cm³
• LogP: 3.05670
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.063743068
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

2-Fluorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36/37/39-27-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2F

Technology Process of 2-Fluorobenzophenone

There total 74 articles about 2-Fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-fluoro-N-phenyl-N-tosylbenzamide + phenylboronic acid (98-80-6) → o-fluorobenzophenone (342-24-5)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; at 110 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.7b00749

Reference yield: 97.0%

1-benzyl-2-fluorobenzene (3794-15-8) → o-fluorobenzophenone (342-24-5)

Guidance literature:

With N-Bromosuccinimide; water; In chloroform; for 3h; Reflux;

DOI:10.1016/j.tetlet.2014.06.047

Reference yield: 97.0%

2-fluorophenylglyoxylic acid (79477-86-4) + potassium phenyltrifluoborate → o-fluorobenzophenone (342-24-5)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; In water; dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1021/ol200459v

upstream raw materials:

1,2-bis-(2-fluoro-phenyl)-1,2-diphenyl-ethane-1,2-diol

Phenetole

2-Fluorobenzoyl chloride

(2-Fluoro-4-trimethylsilanyl-phenyl)-phenyl-methanone

Downstream raw materials:

2-fluoro-α-vinyl-benzhydrol

2-Fluoro-α-ethyl-benzhydrol

(2-(1H-pyrazol-1-yl)phenyl)(phenyl)methanone

4-phenyl-4H-pyrazolo[1,5-a]indol-4-ol

Refernces

• 1、 Huang, Zheng,Liu, Guixia,Qian, Lu,Tang, Xixia,Wang, Yulei. "Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes". supporting information. . Retrieved 2022/02/23.
• 2、 Yu, Tao,Guo, Mingqing,Wen, Simiaomiao,Zhao, Rongrong,Wang, Jinlong,Sun, Yanli,Liu, Qixing,Zhou, Haifeng. "Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen". . p. 13848 - 13852. Retrieved 2021/04/22.