3794-15-8

Basic information

• Product Name: 2-FLUORODIPHENYLMETHANE
• Synonyms: 2-FLUORODIPHENYLMETHANE;1-Benzyl-2-fluorobenzene;2-Fluorodiphenylmethane 99%;2-Fluorodiphenylmethane99%;1-Fluoro-2-(phenylmethyl)benzene
• CAS NO: 3794-15-8
• Molecular Formula: C₁₃H₁₁F
• Molecular Weight: 186.22
• Mol File: 3794-15-8.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 76 °C
• Flash Point: 108.4 °C
• Appearance: /
• Density: 1.08
• Vapor Pressure: 0.0218mmHg at 25°C
• Refractive Index: 1.5586 (589.3 nm 20℃)
• CAS DataBase Reference: 2-FLUORODIPHENYLMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORODIPHENYLMETHANE(3794-15-8)
• EPA Substance Registry System: 2-FLUORODIPHENYLMETHANE(3794-15-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 3794-15-8(Hazardous Substances Data)

Usage

General Description

2-Fluorodiphenylmethane, also known as (2-Fluoro-phenyl)-(phenyl)-methanone, is a chemical compound represented with the formula C13H11FO. This substance belongs to the family of Diphenylmethanes, particularly the group of Fluorodiphenylmethanes. It is used in various fields for diverse applications, but its primary usage is in the domain of pharmaceuticals and research. Its involvement in the formation of different chemical structures makes it an important compound in the development of various drugs and chemicals. Like with other chemical substances, using 2-Fluorodiphenylmethane should be done in accordance with set safety guidelines to prevent mishandling and subsequent health risks.

InChI:InChI=1/C13H11F/c14-13-9-5-4-8-12(13)10-11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 342-24-5 o-fluorobenzophenone 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 100-39-0 benzyl bromide 
• 462-06-6 fluorobenzene 
• 100-44-7 benzyl chloride 
• 101-81-5 Diphenylmethane 
• 362-54-9 2-fluorobenzhydrol 
• 64-19-7 acetic acid 
• 446-48-0 o-fluorobenzyl bromide 
• 98-80-6 phenylboronic acid 
• 100-51-6 benzyl alcohol 
• 446-51-5 2-fluorobenzyl alcohol 
• 71-43-2 benzene 
• 10507-52-5 benzyl N,N-dimethylcarbamate 

Downstream Products

• 106147-79-9 4-[2-(2-Fluoro-phenyl)-2-phenyl-ethyl]-1H-imidazole 
• 342-24-5 o-fluorobenzophenone 
• 3469-20-3 2,3-diphenyl-1H-indole 
• 362-54-9 (R)-(+)-(2-fluorophenyl)(phenyl)methanol 

Relevant articles and documents

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.

Bisulfate Salt-Catalyzed Friedel-Crafts Benzylation of Arenes with Benzylic Alcohols

We report here a method of direct Friedel-Crafts benzylation of arenes with benzylic alcohols using cheap and readily available bisulfate salt as the catalyst in hexafluoroisopropanol. The catalytic system is powerful with a quite diverse group of functionalized arenes and benzylic alcohols. These mild conditions provide a straightforward synthesis of a variety of unsymmetrical diarylmethanes in high yield with good to high regioselectivity. An SN1 mechanism involving activation of the hydroxy group through a hydrogen bond is proposed.

Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel

A nickel-catalyzed cross-coupling to construct the C(sp2)-C(sp3) bond was developed from two sustainable biomass-based feedstocks: phenol derivatives with umpolung aldehydes. This strategy features the in situ generation of moisture/air-stable hydrazones from naturally abundant aldehydes, which act as alkyl nucleophiles under catalysis to couple with readily available phenol derivatives. The avoidance of using both halides as the electrophiles and organometallic or organoboron reagents (also derived from halides) as the nucleophiles makes this method more sustainable. Water tolerance, great functional group (ketone, ester, free amine, amide, etc.) compatibility, and late-stage elaboration of complex biological molecules exemplified its practicability and unique chemoselectivity over organometallic reagents.