Methanone, phenyl[2-(1H-pyrazol-1-yl)phenyl]-

Base Information

• Chemical Name: Methanone, phenyl[2-(1H-pyrazol-1-yl)phenyl]-
• CAS No.: 55317-39-0
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.284
• Mol file: 55317-39-0.mol

Synonyms:

Chemical Property of Methanone, phenyl[2-(1H-pyrazol-1-yl)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanone, phenyl[2-(1H-pyrazol-1-yl)phenyl]-

There total 11 articles about Methanone, phenyl[2-(1H-pyrazol-1-yl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

NH-pyrazole (288-13-1) + o-fluorobenzophenone (342-24-5) → (2-(1H-pyrazol-1-yl)phenyl)(phenyl)methanone (55317-39-0) + 4-phenyl-4H-pyrazolo[1,5-a]indol-4-ol (72419-06-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 130 ℃; for 8h;

Reference yield: 82.0%

1-phenylpyrazole (1126-00-7) + benzyl alcohol (100-51-6,185532-71-2) → (2-(1H-pyrazol-1-yl)phenyl)(phenyl)methanone (55317-39-0)

Guidance literature:

With tert.-butylhydroperoxide; at 110 ℃; for 8h;

DOI:10.1016/j.ica.2016.10.014

Reference yield: 77.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1-phenylpyrazole (1126-00-7) → (2-(1H-pyrazol-1-yl)phenyl)(phenyl)methanone (55317-39-0)

Guidance literature:

With tert.-butylhydroperoxide; palladium dichloride; In decane; 1,2-dichloro-ethane; at 100 ℃; for 24h; Sealed tube;

DOI:10.1002/ejoc.201402782

upstream raw materials:

NH-pyrazole

o-fluorobenzophenone

1-phenylpyrazole

benzonitrile

Downstream raw materials:

α-phenyl-(2-(1H-pyrazol-1-yl))benzyl alcohol

4-phenyl-4H-pyrazolo[1,5-a]indol-4-ol

Refernces

• 1、 Huang, Fei,Wang, Feifan,Hu, Qiyan,Tang, Lin,Xu, Dongping,Fang, Yang,Zhang, Wu. "Monodisperse CuPd alloy nanoparticles as efficient and reusable catalyst for the C (sp2)–H bond activation". . . Retrieved 2021/03/17.
• 2、 Perumgani, C. Pullaiah,Parvathaneni, Sai Prathima,Kodicherla, Balaswamy,Keesara, Srinivas,Mandapati, Mohan Rao. "Polystyrene supported Dichloro-(8-aminoquinoline)-Palladium(II) complex catalyzed C[sbnd]H bond activation for ortho-acylation of 2-aryl pyridines". . p. 105 - 111. Retrieved 2016/11/05.