3-Chloro-4-Methoxybenzoyl Chloride

Base Information

• Chemical Name: 3-Chloro-4-Methoxybenzoyl Chloride
• CAS No.: 36590-49-5
• Molecular Formula: C8H6Cl2O2
• Molecular Weight: 205.04
• Mol file: 36590-49-5.mol

Synonyms:3-chloro-4-methoxy-benzoyl chloride;3-Chloro-4-methoxybenzoyl Chloride;3-Chlor-4-methoxy-benzoylchlorid;3-chloro-4-methoxybenzoic acid chloride;

Chemical Property of 3-Chloro-4-Methoxybenzoyl Chloride

Chemical Property:

• Boiling Point: 120 - 125 °C (1 mmHg)
• PSA: 26.30000
• LogP: 2.72760

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-methoxybenzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-4-methoxybenzoyl Chloride is used in the synthesis of diphenolic azoles as potent estrogen β-receptor ligands, useful in the treatment of certain inflammatory conditions or illnesses. Also is used in the synthesis of N-acetyltransferase inhibitors that act as anti-tubercular agents.

Technology Process of 3-Chloro-4-Methoxybenzoyl Chloride

There total 5 articles about 3-Chloro-4-Methoxybenzoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-methoxy benzoic acid (37908-96-6) → 3-chloro-4-methoxybenzoyl chloride (36590-49-5)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ac60099a016

Reference yield:

oxalyl dichloride (79-37-8) + 3-chloro-4-methoxy benzoic acid (37908-96-6) → 3-chloro-4-methoxybenzoyl chloride (36590-49-5)

Guidance literature:

In chloroform; N,N-dimethyl-formamide;

Reference yield:

4-methoxybenzoic acid (100-09-4) → 3-chloro-4-methoxybenzoyl chloride (36590-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / glacial CH₃COOH, Cl₂ / Ambient temperature

2: SOCl₂, DMF / ethyl acetate / 10 h / Heating

With thionyl chloride; chlorine; acetic acid; N,N-dimethyl-formamide; In ethyl acetate;

DOI:10.1021/jm00393a020

upstream raw materials:

3-chloro-4-methoxy benzoic acid

methyl 3-chloro-p-anisate

4-methoxybenzoic acid

oxalyl dichloride

Downstream raw materials:

3-Chloro-4-methoxy-benzoic acid N'-(4-chloro-phenyl)-hydrazide

3-chloro-4-methoxy-benzoic acid amide

3-chloro-4-methoxy-4'-methylthiobenzophenone

Refernces

• 1、 Ortiz, Gloria,Liu, Pei,Naing, Su Htet Htet,Muller, Vikram R.,Miller, Evan W.. "Synthesis of Sulfonated Carbofluoresceins for Voltage Imaging". . p. 6631 - 6638. Retrieved 2019.
• 2、 Dolensky, Johanna,Hermann, Theresa,Hochegger, Patrick,Kaiser, Marcel,M?ser, Pascal,Saf, Robert,Seebacher, Werner,Weis, Robert. "New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities". . . Retrieved 2021/05/24.
• 3、 -. "SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION". Paragraph 0126-0127. . Retrieved 2020/10/18.