1-(4-Fluorophenyl)-2-phenylethane

Base Information

• Chemical Name: 1-(4-Fluorophenyl)-2-phenylethane
• CAS No.: 370-76-3
• Molecular Formula: C14H13F
• Molecular Weight: 200.256
• Hs Code.: 2903999090
• Mol file: 370-76-3.mol

Synonyms:Benzene,1-fluoro-4-(2-phenylethyl);1-fluoro-4-phenethylbenzene;1-(4-fluorophenyl)-2-phenylethane;4-Fluor-bibenzyl;L-(4-Fluorophenyl)-2-phenylethane;4-fluorobibenzyl;Bibenzyl,4-fluoro;

Chemical Property of 1-(4-Fluorophenyl)-2-phenylethane

Chemical Property:

• Vapor Pressure: 0.0161mmHg at 25°C
• Boiling Point: 264.2°C at 760 mmHg
• Flash Point: 121.4°C
• PSA: 0.00000
• Density: 1.069g/cm³
• LogP: 3.61090

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Fluorophenyl)-2-phenylethane

There total 17 articles about 1-(4-Fluorophenyl)-2-phenylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

bromobenzene (108-86-1,52753-63-6) + para-fluorostyrene (405-99-2) → 1-(4-fluorophenyl)-2-phenylethane (370-76-3)

Guidance literature:

bromobenzene; para-fluorostyrene; With sodium acetate; In N,N-dimethyl acetamide; at 100 ℃; Inert atmosphere;

With hydrogen; In N,N-dimethyl acetamide; at 20 ℃; under 760.051 Torr;

DOI:10.1002/adsc.200800460

Reference yield: 96.0%

(4-fluorophenyl)phenylacetylene (405-29-8) → 1-(4-fluorophenyl)-2-phenylethane (370-76-3)

Guidance literature:

With isopropyl alcohol; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1039/c5sc00933b

Reference yield: 86.0%

2-(2-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1065498-70-5) + chlorobenzene (108-90-7) → 1-(4-fluorophenyl)-2-phenylethane (370-76-3)

Guidance literature:

With potassium tert-butylate; palladium diacetate; ruphos; In water; toluene; at 80 ℃; for 24h; Schlenk technique; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201310096

upstream raw materials:

(4-fluorophenyl)phenylacetylene

N-(4-fluorobenzyl)-2-phenylacetamide

cis-4-fluorostilbene

(E)-4-fluorostilbene

Refernces

• 1、 Yang, Xu-Wen,Li, Dong-Hui,Song, A-Xiang,Liu, Feng-Shou. ""bulky-Yet-Flexible" α-Diimine Palladium-Catalyzed Reductive Heck Cross-Coupling: Highly Anti-Markovnikov-Selective Hydroarylation of Alkene in Air". . p. 11750 - 11765. Retrieved 2020/10/23.
• 2、 Kim, Ye Ji,Kim, Sun Min,Cho, Eun Jin,Hosono, Hideo,Yang, Jung Woon,Kim, Sung Wng. "Two dimensional inorganic electride-promoted electron transfer efficiency in transfer hydrogenation of alkynes and alkenes". . p. 3577 - 3581. Retrieved 2015/05/27.