RETUSIN 7,8-DIMETHYLETHER

Base Information

• Chemical Name: RETUSIN 7,8-DIMETHYLETHER
• CAS No.: 37816-21-0
• Molecular Formula: C18H16O5
• Molecular Weight: 312.322
• Hs Code.: 2914509090
• Mol file: 37816-21-0.mol

Synonyms:retusin dimethyl ether;retusine 7,8-dimethyl ether;7,8,4''-trimethoxyisoflavone;4'',7,8-Trimethoxyisoflavon;4'',7,8-trimethoxyisoflavone;

Chemical Property of RETUSIN 7,8-DIMETHYLETHER

Chemical Property:

• PSA: 57.90000
• LogP: 3.48580

Purity/Quality:

99% ^*data from raw suppliers

7,8,4'-Trimethoxyisoflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RETUSIN 7,8-DIMETHYLETHER

There total 16 articles about RETUSIN 7,8-DIMETHYLETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7,8-dimethoxy-2-(4-methoxy-phenyl)-chroman-4-one (57499-10-2) → 4′,7,8-trimethoxyisoflavone (37816-21-0)

Guidance literature:

With thallium(III) toluene-p-sulfonate; In acetonitrile; for 2h; Heating;

Reference yield: 92.0%

1,3,5-Triazine (290-87-9) + 1-(2-hydroxy-3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone (3606-32-4) → 4′,7,8-trimethoxyisoflavone (37816-21-0)

Guidance literature:

With boron trifluoride diethyl etherate; acetic anhydride; In diethyl ether; acetic acid; Heating;

Reference yield: 70.0%

8-bromo-4′,7-dimethoxyisoflavone (117375-28-7) + sodium methylate (124-41-4) → 4′,7,8-trimethoxyisoflavone (37816-21-0)

Guidance literature:

sodium methylate; With copper(I) bromide; In methanol; N,N-dimethyl-formamide; for 1h;

8-bromo-4′,7-dimethoxyisoflavone; In methanol; N,N-dimethyl-formamide; at 120 ℃; for 2h;

upstream raw materials:

1,3,5-Triazine

1-(2-hydroxy-3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

retusin

dimethyl sulfate

Downstream raw materials:

C₁₈H₁₈N₂O₄

8-hydroxydaidzein

7,8,4'-trimethoxyisoflavanone

formic acid

Refernces

• 1、 -. "Synthetic method of polyhydroxy isoflavone". Paragraph 0047; 0049; 0052-0053. . Retrieved 2020/09/09.
• 2、 Singh, Om V.,Muthukrishnan,Sunderavadivelu. "Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate". . p. 2575 - 2581. Retrieved 2007/10/03.