METHYLPHENYLPHOSPHINIC ACID

Base Information

• Chemical Name: METHYLPHENYLPHOSPHINIC ACID
• CAS No.: 4271-13-0
• Molecular Formula: C7H9 O2 P
• Molecular Weight: 156.121
• Hs Code.: 2916399090
• Mol file: 4271-13-0.mol

Synonyms:Phosphinicacid, methylphenyl- (6CI,7CI,8CI,9CI); Methylphenylphosphinic acid; NSC 403102

Chemical Property of METHYLPHENYLPHOSPHINIC ACID

Chemical Property:

• Vapor Pressure: 2.98E-06mmHg at 25°C
• Melting Point: 132-134oC
• Boiling Point: 373.9°C at 760 mmHg
• PKA: 2.43±0.50(Predicted)
• Flash Point: 179.9°C
• PSA: 47.11000
• Density: 1.2g/cm³
• LogP: 1.21210

Purity/Quality:

98%,99%, ^*data from raw suppliers

methyl(phenyl)phosphinicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of METHYLPHENYLPHOSPHINIC ACID

There total 32 articles about METHYLPHENYLPHOSPHINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

→ methylphenylphosphinic acid (4271-13-0) + 5-chloro-4-methyl-2-phenyl-3a,7a-dihydro-isoindole-1,3-dione + 5-chloro-6-methyl-2-phenyl-3a,7a-dihydro-isoindole-1,3-dione

Guidance literature:

With water; In acetonitrile; at 26 ℃; for 2h; Irradiation;

DOI:10.1016/S0022-328X(98)00855-9

Reference yield: 66.0%

phenylphosphinic acid (1779-48-2) + methyl iodide (74-88-4) → methylphenylphosphinic acid (4271-13-0)

Guidance literature:

phenylphosphinic acid; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c01151

Reference yield:

water (7732-18-5) + methyl-phenyl-dipiperidino-phosphonium; iodide → piperidine (110-89-4) + methylphenylphosphinic acid (4271-13-0)

Guidance literature:

at 150 ℃;

upstream raw materials:

piperidine

Dichlorophenylphosphine

phenyl methylphenylphosphinate

1,2-dimethyl-1,2-diphenyldiphosphine

Downstream raw materials:

Cu(O₂P(CH₃)(C₆H₅))2(OCHNH₂)

Co(O₂P(CH₃)(C₆H₅))2(OCHNH₂)

methyl-phenylphosphinicacid-fluoride

methyl-N,P-diphenylphosphinic amide

Refernces

• 1、 Winters, Karen R.,Montchamp, Jean-Luc. "Evaluation and development of methodologies for the synthesis of thiophosphinic acids". . p. 14545 - 14558. Retrieved 2020/12/29.
• 2、 Nowlan, Charity,Li, Yingchun,Hermann, Johannes C.,Evans, Timothy,Carpenter, Joseph,Ghanem, Eman,Shoichet, Brian K.,Raushel, Frank M.. "Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library". . p. 15892 - 15902. Retrieved 2007/10/03.