methyl-N,P-diphenylphosphinic amide

Base Information

• Chemical Name: methyl-N,P-diphenylphosphinic amide
• CAS No.: 51703-89-0
• Molecular Formula: C₁₃H₁₄NOP
• Molecular Weight: 231.234
• Mol file: 51703-89-0.mol

Synonyms:methyl-N,P-diphenylphosphinic amide

Chemical Property of methyl-N,P-diphenylphosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl-N,P-diphenylphosphinic amide

There total 7 articles about methyl-N,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methylphenylphosphinic acid (4271-13-0) + aniline (62-53-3) → methyl-N,P-diphenylphosphinic amide (51703-89-0)

Guidance literature:

methylphenylphosphinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01151

Reference yield:

methyl(phenyl)phosphinic chloride (5761-97-7) + aniline (62-53-3) → methyl-N,P-diphenylphosphinic amide (51703-89-0) + aniline hydrochloride (142-04-1,36663-09-9)

Guidance literature:

In acetonitrile; at 55 ℃; Kinetics;

DOI:10.1002/poc.1478

Reference yield:

methyl(phenyl)phosphinic chloride (5761-97-7) → methyl-N,P-diphenylphosphinic amide (51703-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 20 °C

2: dimethyl sulfoxide / 60 °C

With triethylamine; In dimethyl sulfoxide; acetonitrile;

DOI:10.1039/c0ob00517g

upstream raw materials:

methyl(phenyl)phosphinic chloride

aniline

phenyl methylphenylphosphinate

Methyl-phenyl-phosphinsaeure-(p)-nitrophenylester

Downstream raw materials:

methylphenylphosphinothioic acid

Refernces

• 1、 Dey, Nilay Kumar,Kim, Chan Kyung,Lee, Hai Whang. "Kinetics and mechanism of the anilinolyses of aryl dimethyl, methyl phenyl and diphenyl phosphinates". scheme or table. p. 717 - 724. Retrieved 2011/04/16.