H-ACH-OME

Base Information

• Chemical Name: H-ACH-OME
• CAS No.: 37993-32-1
• Molecular Formula: C8H15NO2.ClH
• Molecular Weight: 193.674
• Mol file: 37993-32-1.mol

Synonyms:methyl 1-aminocyclohexane-1-carboxylate,hydrochloride;

Chemical Property of H-ACH-OME

Chemical Property:

• Melting Point: 210-212 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• PSA: 52.32000
• LogP: 2.32330
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%+, ^*data from raw suppliers

Methyl1-aminocyclohexanecarboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ACH-OME

There total 6 articles about H-ACH-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 1-aminocyclohexane carboxylic acid (2756-85-6) → 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride (37993-32-1)

Guidance literature:

With thionyl chloride; at -5 - 80 ℃; for 3h;

DOI:10.1002/asia.202101158

Reference yield: 100.0%

1-aminocyclohexane carboxylic acid (2756-85-6) + acetyl chloride (75-36-5) → 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride (37993-32-1)

Guidance literature:

In methanol; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1021/ol302096j

Reference yield: 100.0%

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride (37993-32-1)

Guidance literature:

upstream raw materials:

methanol

1-aminocyclohexane carboxylic acid

spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione

cyclohexanone

Downstream raw materials:

2-Acetyl-4-(4-chloro-phenyl)-1,3,4-triaza-spiro[5.5]undec-2-en-5-one

methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

Refernces

• 1、 -. "A COMPOUND FOR INHIBITING 11B-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME". Paragraph 0482-0484. . Retrieved 2014/08/06.
• 2、 Maegawa, Tomohiro,Otake, Kazuki,Hirosawa, Keiichi,Goto, Akihiro,Fujioka, Hiromichi. "Method for the efficient synthesis of highly-substituted oxetan- and azetidin-, dihydrofuran- and pyrrolidin-3-ones and its application to the synthesis of (±)-pseudodeflectusin". supporting information. p. 4798 - 4801. Retrieved 2013/01/15.