1-(1-BROMONAPHTHALEN-4-YL)ETHANONE

Base Information

• Chemical Name: 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE
• CAS No.: 46258-62-2
• Molecular Formula: C12H9BrO
• Molecular Weight: 249.107
• Hs Code.: 2914700090
• Mol file: 46258-62-2.mol

Synonyms:4-bromo-1-acetonaphthone;CSVHMWORIJZGTJ-UHFFFAOYSA;4-bromo-1-acetylnaphthalene;1-acetyl-4-bromo-naphthalene;

Chemical Property of 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE

Chemical Property:

• Vapor Pressure: 1.12E-05mmHg at 25°C
• Melting Point: 50-51oC
• Boiling Point: 370℃
• Flash Point: 114℃
• PSA: 17.07000
• Density: 1.454
• LogP: 3.80490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Bromonaphthalen-1-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE

There total 6 articles about 1-(1-BROMONAPHTHALEN-4-YL)ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(4-Bromo-α-naphthyl)ethyl alcohol (58149-70-5) → 1-(4-bromonaphthalen-1-yl)ethanone (46258-62-2)

Guidance literature:

With tert.-butylhydroperoxide; In water; at 100 ℃; for 24h;

DOI:10.1080/00397911.2016.1223307

Reference yield: 91.0%

1-Bromonaphthalene (90-11-9) + acetyl chloride (75-36-5) → 1-(4-bromonaphthalen-1-yl)ethanone (46258-62-2)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 24h;

Reference yield:

1,4-dibromonaphthalene (83-53-4) + tributyl(1-ethoxyvinyl)stannane (97674-02-7) → 1-(4-bromonaphthalen-1-yl)ethanone (46258-62-2)

Guidance literature:

1,4-dibromonaphthalene; tributyl(1-ethoxyvinyl)stannane; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 100 ℃; Inert atmosphere;

With potassium fluoride; In toluene; at 20 ℃; for 2h;

upstream raw materials:

1-Bromonaphthalene

acetyl chloride

acetic anhydride

carbon disulfide

Downstream raw materials:

2-(1-bromonaphthalen-4-yl)-1,10-phenanthroline

4-bromo-1-naphthoic acid chloride

JWH-394

(4-bromo-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone

Refernces

• 1、 -. "Preparation method of 1,4-naphthalic acid". Paragraph 0018. . Retrieved 2021/05/12.
• 2、 Wu, Jianglong,Liu, Yan,Ma, Xiaowei,Liu, Ping,Gu, Chengzhi,Dai, Bin. "Cu(II)-Catalyzed Ligand-Free Oxidation of Diarylmethanes and Second Alcohols in Water". supporting information. p. 1391 - 139. Retrieved 2017/09/30.