2-phenyl-N,N-dipropylacetamide

Base Information

• Chemical Name: 2-phenyl-N,N-dipropylacetamide
• CAS No.: 25173-09-5
• Molecular Formula: C14H21 N O
• Molecular Weight: 219.327
• Mol file: 25173-09-5.mol

Synonyms:Acetamide,2-phenyl-N,N-dipropyl- (8CI); N,N-Dipropylphenylacetamide; NSC 406534

Chemical Property of 2-phenyl-N,N-dipropylacetamide

Chemical Property:

• Vapor Pressure: 9.32E-05mmHg at 25°C
• Boiling Point: 339.2°C at 760 mmHg
• Flash Point: 146.9°C
• Density: 0.971g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-N,N-dipropylacetamide

There total 6 articles about 2-phenyl-N,N-dipropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-n-propylamine (142-84-7) + phenylacetyl chloride (103-80-0) → N,N-dipropyl-2-phenylacetamide (25173-09-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1002/ardp.200300776

Reference yield: 88.0%

di-n-propylamine (142-84-7) + 1-Bromo-2-phenylacetylene (932-87-6) → N,N-dipropyl-2-phenylacetamide (25173-09-5)

Guidance literature:

With water; at 120 ℃; for 6h;

DOI:10.1016/j.tet.2011.06.045

Reference yield: 73.0%

carbon monoxide (201230-82-2) + N-benzyl-N,N-dipropylamine (20441-12-7) → N,N-dipropyl-2-phenylacetamide (25173-09-5)

Guidance literature:

N-benzyl-N,N-dipropylamine; With ortho-diphenylphosphinobenzoic acid; nickel dichloride; for 0.5h; Glovebox; Autoclave;

carbon monoxide; With iodine; at 140 ℃; for 48h; under 15201 Torr; Glovebox; Autoclave;

DOI:10.1021/acs.orglett.7b01488

upstream raw materials:

di-n-propylamine

phenylacetyl chloride

phenylacetic acid

1-Bromo-2-phenylacetylene

Downstream raw materials:

N-2-(phenylethyl)-N,N-dipropyl-amine

Refernces

• 1、 Yu, Hui,Gao, Bao,Hu, Bin,Huang, Hanmin. "Charge-Transfer Complex Promoted C-N Bond Activation for Ni-Catalyzed Carbonylation". supporting information. p. 3520 - 3523. Retrieved 2017/07/17.
• 2、 Chen, Zheng-Wang,Jiang, Huan-Feng,Pan, Xiao-Yan,He, Zai-Jun. "Practical synthesis of amides from alkynyl bromides, amines, and water". experimental part. p. 5920 - 5927. Retrieved 2011/09/19.