1-(2-aMino-4-chlorophenyl)ethanone

Base Information

• Chemical Name: 1-(2-aMino-4-chlorophenyl)ethanone
• CAS No.: 39061-72-8
• Molecular Formula: C8H8ClNO
• Molecular Weight: 169.611
• Hs Code.: 2922399090
• Mol file: 39061-72-8.mol

Synonyms:2-acetyl-5-chloroaniline;2-amino-4-chloroacetophenone;

Chemical Property of 1-(2-aMino-4-chlorophenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.000607mmHg at 25°C
• Melting Point: 90 °C
• Boiling Point: 310.2oC at 760 mmHg
• PKA: 1.25±0.10(Predicted)
• Flash Point: 141.4oC
• PSA: 43.09000
• Density: 1.254g/cm3
• LogP: 2.70600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

1-(2-Amino-4-chlorophenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-aMino-4-chlorophenyl)ethanone

There total 18 articles about 1-(2-aMino-4-chlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide (675578-62-8) → 2-acetyl-5-chloroaniline (39061-72-8)

Guidance literature:

N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide; With sulfuric acid; at 0 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With sodium hydrogencarbonate; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41915k

Reference yield: 98.0%

4'-chloro-2'-nitroacetophenone (23082-51-1) → 2-acetyl-5-chloroaniline (39061-72-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water;

DOI:10.1016/j.bmcl.2012.10.066

Reference yield: 96.0%

2-amino-4-chlorobenzonitrile (38487-86-4) + methylmagnesium chloride (676-58-4) → 2-acetyl-5-chloroaniline (39061-72-8)

Guidance literature:

2-amino-4-chlorobenzonitrile; methylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 - 25 ℃; for 3.33333h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; at -60 - 18 ℃; for 3h;

With potassium hydroxide; In water; pH=9; Product distribution / selectivity;

upstream raw materials:

4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid

sodium diethylmalonate

4'-chloro-2'-nitroacetophenone

2-Amino-4-chlorobenzoic acid

Downstream raw materials:

N-(2-acetyl-5-chlorophenyl)formamide

1-[4-chloro-2-(2-methylbenzoyl)aminophenyl]ethanone

N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide

7-chloro-4-methyl-2-phenylquinoline

Refernces

• 1、 Lázaro-Milla, Carlos,Almendros, Pedro. "A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines". supporting information. p. 13534 - 13538. Retrieved 2021/08/13.
• 2、 Xia, Hai-Dong,Zhang, Yan-Dong,Wang, Yan-Hui,Zhang, Chi. "Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles". supporting information. p. 4052 - 4056. Retrieved 2018/07/15.