Dimethyl piperazine-1,4-dipropionate

Base Information

• Chemical Name: Dimethyl piperazine-1,4-dipropionate
• CAS No.: 4038-90-8
• Molecular Formula: C12H22 N2 O4
• Molecular Weight: 258.318
• Hs Code.: 2933599090
• European Community (EC) Number: 223-724-0
• DSSTox Substance ID: DTXSID70193372
• Nikkaji Number: J76.693C
• Wikidata: Q83066098
• Mol file: 4038-90-8.mol

Synonyms:Dimethyl piperazine-1,4-dipropionate;4038-90-8;EINECS 223-724-0;1,4-Piperazinedipropionic acid, dimethyl ester;Oprea1_718208;Oprea1_819047;SCHEMBL4489670;DTXSID70193372;dimethyl piperazine-1,4-dipropanoate;AKOS017267652;Piperazine-1,4-dipropanoic acid dimethyl ester;dimethyl 3,3'-(piperazine-1,4-diyl)dipropanoate

Chemical Property of Dimethyl piperazine-1,4-dipropionate

Chemical Property:

• Vapor Pressure: 8.63E-05mmHg at 25°C
• Boiling Point: 340.4°Cat760mmHg
• Flash Point: 159.7°C
• PSA: 59.08000
• Density: 1.091g/cm³
• LogP: -0.39400
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 258.15795719
• Heavy Atom Count: 18
• Complexity: 247

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CCN1CCN(CC1)CCC(=O)OC

Technology Process of Dimethyl piperazine-1,4-dipropionate

There total 3 articles about Dimethyl piperazine-1,4-dipropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

piperazine (110-85-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-[4-(2-methoxycarbonylethyl)piperazin-1-yl]propionic acid methyl ester (4038-90-8)

Guidance literature:

In toluene; at 200 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jo060692v

Reference yield: 88.0%

piperazine (110-85-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-(2-methoxycarbonylethyl)piperazine (43032-40-2) + 3-[4-(2-methoxycarbonylethyl)piperazin-1-yl]propionic acid methyl ester (4038-90-8)

Guidance literature:

With [bmim]BF₄; copper acetylacetonate; at 20 ℃; for 0.333333h;

DOI:10.1002/adsc.200404361

Reference yield:

→ 3-[4-(2-methoxycarbonylethyl)piperazin-1-yl]propionic acid methyl ester (4038-90-8)

Guidance literature:

Piperazin, Acrylsaeure-methylester;

DOI:10.1007/BF00908805

upstream raw materials:

piperazine

acrylic acid methyl ester

Refernces

• 1、 Trivedi, Rajiv,Lalitha,Roy, Sarabindu. "Vanadyl(IV) acetate: An efficient, reusable heterogenous catalyst for Aza-Michael reaction under solvent-free conditions". . p. 3556 - 3566. Retrieved 2008/12/23.
• 2、 Reddy, K. Rajender,Kumar, Nadakudity S.. "Cellulose-supported copper(0) catalyst for aza-Michael addition". . p. 2246 - 2250. Retrieved 2007/10/03.