Technology Process of (4alpha)-15-(acetyloxy)-3-oxo-12,13-epoxytrichothec-9-en-4-yl chloroacetate
There total 6 articles about (4alpha)-15-(acetyloxy)-3-oxo-12,13-epoxytrichothec-9-en-4-yl chloroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethyl sulfoxide; trifluoroacetic anhydride;
In
dichloromethane;
at -78 ℃;
for 0.5h;
DOI:10.1021/jm00347a018
- Guidance literature:
-
In
diethyl ether; hexane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / p-toluenesulfonic acid / CH2Cl2 / 2 h / Ambient temperature
2: 38 percent / aq. NH4OH / methanol; tetrahydrofuran / 168 h / Ambient temperature
3: 83 percent / pyridine / CH2Cl2 / 64 h / Ambient temperature
4: 80 percent / 10percent aq. HCl / aq. ethanol / 40 h / Ambient temperature
5: 86 percent / trifluoroacetic anhydride, Me2SO / CH2Cl2 / 0.5 h / -78 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic anhydride;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00347a018
