(+)-Gmelinol

Base Information Edit

Chemical Name:(+)-Gmelinol
CAS No.:469-28-3
Molecular Formula:C22H26O7
Molecular Weight:402.4376
Hs Code.:
UNII:BX2Y2S5M5Y
Nikkaji Number:J1.192.824B
Wikipedia:Gmelinol
Mol file:469-28-3.mol

Synonyms:gmelinol

Suppliers and Price of (+)-Gmelinol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (+)-Gmelinol Edit

Chemical Property:

Vapor Pressure:2.17E-13mmHg at 25°C
Boiling Point:560.3°C at 760 mmHg
Flash Point:292.7°C
Density:1.253g/cm³
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:402.16785316
Heavy Atom Count:29
Complexity:545

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2C3COC(C3(CO2)O)C4=CC(=C(C=C4)OC)OC)OC
Isomeric SMILES:COC1=C(C=C(C=C1)[C@H]2[C@H]3CO[C@@H]([C@]3(CO2)O)C4=CC(=C(C=C4)OC)OC)OC

Technology Process of (+)-Gmelinol

There total 20 articles about (+)-Gmelinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 144918-25-2
(4S,5R)-4-(3,4-Dimethoxy-benzyloxymethyl)-5-(3,4-dimethoxy-phenyl)-dihydro-furan-3-one

: 469-28-3,597-01-3,17669-45-3,24192-66-3,81495-56-9,96894-16-5,144940-45-4
(+/-)-Isogmelinol

Guidance literature:: In benzene; for 0.75h; Irradiation;
DOI:10.1016/S0040-4039(00)61118-8 DOI:10.1016/S0040-4020(01)81924-4

Reference yield:

: 144918-23-0
2-(3,4-dimethoxyphenyl)-3-(hydroxymethyl)-4-methylenetetrahydrofuran

: 469-28-3,597-01-3,17669-45-3,24192-66-3,81495-56-9,96894-16-5,144940-45-4
(+/-)-Isogmelinol

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / NaH / 1,2-dimethoxy-ethane / 20 h / Heating

2: 90 percent / NaIO₄, OsO₄ / diethyl ether; H₂O / 24 h / Ambient temperature

3: 72 percent / benzene / 0.75 h / Irradiation

With sodium periodate; osmium(VIII) oxide; sodium hydride; In 1,2-dimethoxyethane; diethyl ether; water; benzene;
DOI:10.1016/S0040-4020(01)81924-4

Reference yield:

: 144918-21-8
ethyl 2-bromo-3-(3,4-dimethoxyphenyl)-3-(prop-2-ynyloxy)propanoate

: 469-28-3,597-01-3,17669-45-3,24192-66-3,81495-56-9,96894-16-5,144940-45-4
(+/-)-Isogmelinol

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / n-Bu₃SnH, AIBN / benzene / 4 h / Heating

2: 97 percent / LiAlH₄ / diethyl ether / 3 h / Heating

3: 76 percent / NaH / 1,2-dimethoxy-ethane / 20 h / Heating

4: 90 percent / NaIO₄, OsO₄ / diethyl ether; H₂O / 24 h / Ambient temperature

5: 72 percent / benzene / 0.75 h / Irradiation

With sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In 1,2-dimethoxyethane; diethyl ether; water; benzene;
DOI:10.1016/S0040-4020(01)81924-4