N,N-DIMETHYL-2-FLUOROANILINE

Base Information

• Chemical Name: N,N-DIMETHYL-2-FLUOROANILINE
• CAS No.: 393-56-6
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 2921420090
• Mol file: 393-56-6.mol

Synonyms:2-fluoro-N,N-dimethyl-aniline;o-Fluor-N,N-dimethyl-anilin;2-Fluor-N,N-dimethyl-anilin;Benzenamine, 2-fluoro-N,N-dimethyl-;2-fluoro-N,N-dimethyl-benzenamine;N,N-Dimethyl-2-fluoro-4-phenylazoaniline;4-Dimethylamino-3-fluor-azobenzol;ANILINE,N,N-DIMETHYL-2-FLUORO-4-PHENYLAZO;2-Fluoro-4-dimethylaminoazobenzene;2-Fluor-N,N-dimethyl-4-phenylazo-anilin;2-fluoro-N,N-dimethyl-4-phenylazo-aniline;

Chemical Property of N,N-DIMETHYL-2-FLUOROANILINE

Chemical Property:

• Boiling Point: 66-67 °C(Press: 13 Torr)
• PKA: 4.93±0.18(Predicted)
• PSA: 3.24000
• Density: 1.057±0.06 g/cm3(Predicted)
• LogP: 1.89170
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-N,N-dimethylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIMETHYL-2-FLUOROANILINE

There total 11 articles about N,N-DIMETHYL-2-FLUOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Fluoroaniline (348-54-9) + carbon dioxide (124-38-9,18923-20-1) → 2-fluoro-N,N-dimethylaniline (393-56-6)

Guidance literature:

With [Ru(Triphos)(TMM)]; hydrogen; bis(trifluoromethanesulfonyl)amide; In tetrahydrofuran; at 150 ℃; for 24h; under 60006 Torr; Inert atmosphere;

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Fluoroaniline (348-54-9) → 2-fluoro-N,N-dimethylaniline (393-56-6)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; at 23 - 50 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.joc.8b01590

Reference yield: 64.0%

2-bromo-N,N-dimethylaniline (698-00-0) → 2-fluoro-N,N-dimethylaniline (393-56-6)

Guidance literature:

2-bromo-N,N-dimethylaniline; With magnesium; lithium chloride; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans); at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1218816

upstream raw materials:

2-fluoro-tri-N-methyl-anilinium; iodide

2-Fluoroaniline

dimethyl sulfate

2-bromo-N,N-dimethylaniline

Downstream raw materials:

2-fluoro-tri-N-methyl-anilinium; iodide

N-(2-fluorophenyl)formamide

2-fluoro-N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

trans-3-Fluor-4-dimethylamino-azobenzol

Refernces

• 1、 -. "Method for preparing important chemicals by using lignin as methyl sources". Paragraph 0097; 0098; 0120-0124. . Retrieved 2019/06/12.
• 2、 Reed, Hayley,Paul, Tyler R.,Chain, William J.. "Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides". . p. 11359 - 11368. Retrieved 2018/08/06.