Formamide, N-[1-methyl-1-[3-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethyl]-

Base Information

• Chemical Name: Formamide, N-[1-methyl-1-[3-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethyl]-
• CAS No.: 40396-57-4
• Molecular Formula: C18H17F4NO
• Molecular Weight: 339.333
• Mol file: 40396-57-4.mol

Synonyms:

Chemical Property of Formamide, N-[1-methyl-1-[3-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formamide, N-[1-methyl-1-[3-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethyl]-

There total 5 articles about Formamide, N-[1-methyl-1-[3-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-bromophenyl)-2-phenylethane-1,2-dione (40396-54-1) → N-[α,α-dimethyl-3-(α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide (40396-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SF₄, Hg, HF / benzene

2: (i) Mg, I₂, Et₂O, (ii) /BRN= 635680/

3: H₂SO₄ / acetic acid

With sulfuric acid; sulfur tetrafluoride; hydrogen fluoride; mercury; In acetic acid; benzene;

DOI:10.1021/jm00213a021

Reference yield:

3-bromo-α,α,α',α'-tetrafluorobibenzyl (40396-55-2) → N-[α,α-dimethyl-3-(α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide (40396-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) Mg, I₂, Et₂O, (ii) /BRN= 635680/

2: H₂SO₄ / acetic acid

With sulfuric acid; In acetic acid;

DOI:10.1021/jm00213a021

Reference yield:

benzyl chloride (100-44-7) → N-[α,α-dimethyl-3-(α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide (40396-57-4)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) Mg, Et₂O, (ii) /BRN= 1858942/, (iii) aq. citric acid

2: aq. H₂SeO₃ / dioxane / Heating

3: SF₄, Hg, HF / benzene

4: (i) Mg, I₂, Et₂O, (ii) /BRN= 635680/

5: H₂SO₄ / acetic acid

With sulfuric acid; sulfur tetrafluoride; hydrogen fluoride; selenious acid; mercury; In 1,4-dioxane; acetic acid; benzene;

DOI:10.1021/jm00213a021

upstream raw materials:

2-<3-(α,α,β,β-Tetrafluorphenethyl)phenyl>propan-2-ol

sodium cyanide

1-(3-bromophenyl)-2-phenylethane-1,2-dione

3-bromo-α,α,α',α'-tetrafluorobibenzyl

Refernces

• 1、 -. "Tetrafluorophenethylaralkylamine compounds". . . Retrieved 2008/06/13.