1H-Imidazole-4-acetic acid, methyl ester

Base Information

• Chemical Name: 1H-Imidazole-4-acetic acid, methyl ester
• CAS No.: 4200-46-8
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.142
• Hs Code.: 2933290090
• Mol file: 4200-46-8.mol

Synonyms:methyl 4-Imidazoleacetate;1H-Imidazole-4-acetic acid,methyl ester;methyl imidazole-4-acetate;4-imidazoleacetic acid methyl ester;methyl 1H-imidazol-4-ylacetate;

Chemical Property of 1H-Imidazole-4-acetic acid, methyl ester

Chemical Property:

• PSA: 54.98000
• LogP: 0.12520
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

methyl2-(1H-imidazol-5-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-4-acetic acid, methyl ester

There total 7 articles about 1H-Imidazole-4-acetic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + imidazole-4-acetic acid sodium salt → (1H-imidazol-4-yl)-acetic acid methyl ester (4200-46-8)

Guidance literature:

With hydrogenchloride; at 0 - 20 ℃; for 4.66667h;

Reference yield: 99.0%

methanol (67-56-1) + 2-(1H-imidazol-4-yl)acetic acid (645-65-8) → (1H-imidazol-4-yl)-acetic acid methyl ester (4200-46-8)

Guidance literature:

With thionyl chloride; for 4h; Reflux;

DOI:10.1002/chem.201504520

Reference yield: 66.0%

imidazole-4-acetic acid hydrochloride (3251-69-2) → 1'-[2-(3H-imidazol-4-yl)-ethyl]-3,3-dimethyl-1',2',3',4',5',6'-hexahydro-[2,2';6',2]terpyridine (HBr Salt) + (1H-imidazol-4-yl)-acetic acid methyl ester (4200-46-8)

Guidance literature:

With sulfuric acid; sodium chloride; In methanol; dichloromethane;

upstream raw materials:

methanol

imidazole-4-acetic acid hydrochloride

2-(1H-imidazol-4-yl)acetic acid

Downstream raw materials:

imidazoleacetic acid riboside

methyl 2-<azo>imidazole-4(5)-acetate

2-(1H-imidazol-4-yl)-2-methylpropanoic acid

(±)-2-(1-yrityl-1H-imidazol-4-yl)propanoic acid

Refernces

• 1、 Krall, Jacob,Brygger, Benjamin M.,Sigureardóttir, Sara B.,Ng, Clarissa K. L.,Bundgaard, Christoffer,Kehler, Jan,Nielsen, Birgitte,Bek, Toke,Jensen, Anders A.,Fr?lund, Bente. "Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone". . p. 2299 - 2310. Retrieved 2016/10/25.
• 2、 -. "CYCLOPROPANECARBOXYLIC ACID DERIVATIVE". Paragraph 0354-0357. . Retrieved 2013/03/26.