DL-Homoserine Lactone hydrochloride

Base Information

• Chemical Name: DL-Homoserine Lactone hydrochloride
• CAS No.: 42417-39-0
• Molecular Formula: C4H7NO2.ClH
• Molecular Weight: 137.566
• Mol file: 42417-39-0.mol

Synonyms:α-amino-γ-butyrolactone-hydrochloride;homoserine γ-lactone hydrochloride;racemic homoserine chlorhydrate;3-aminodihydro-2(3H)-furanone hydrochloride;homoserine lactone;α-amino-γ-butyrolacton hydrochloride;

Chemical Property of DL-Homoserine Lactone hydrochloride

Chemical Property:

• Melting Point: 201-203 °C
• PSA: 52.32000
• LogP: 0.76290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminodihydrofuran-2(3H)-onehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-Homoserine Lactone hydrochloride

There total 5 articles about DL-Homoserine Lactone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-aminobutyrolactone (1192-20-7) → (RS)-α-amino-γ-butyrolactone hydrochloride (42417-39-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

Reference yield: 81.0%

3-(2,2-diphenylhydrazino)dihydro-2(3H)-furanone (189334-61-0) → (RS)-α-amino-γ-butyrolactone hydrochloride (42417-39-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1039/a608236j

Reference yield: 70.6%

α-bromo-γ-butyrolactone (5061-21-2) → (RS)-α-amino-γ-butyrolactone hydrochloride (42417-39-0)

Guidance literature:

α-bromo-γ-butyrolactone; With ammonium hydroxide; for 48h; Cooling with ice;

With hydrogenchloride; at 110 ℃; for 1h;

upstream raw materials:

DL-Homoserine

3-(2,2-diphenylhydrazino)dihydro-2(3H)-furanone

2-aminobutyrolactone

chloroacetic acid

Downstream raw materials:

L-homoserine lactone hydrochloride

(R)-(+)-α-amino-γ-butyrolactone hydrochloride

C₁₅H₁₇NO₄

DL-methionine

Refernces

• 1、 -. "A cogeneration process for producing sulfur and sulfur on behalf of acetate acid diester method (by machine translation)". Paragraph 0055; 0057. . Retrieved 2018/12/02.
• 2、 Clive,Zhang,Subedi,Bouetard,Hiebert,Ewanuk. "Preparation of α-(2,2-diphenylhydrazino)lactones and related compounds by radical cyclization: Use of glyoxylic acid hydrazone derivatives". . p. 1233 - 1241. Retrieved 2007/10/03.