5061-21-2

Basic information

• Product Name: 2-Bromo-4-butanolide
• Synonyms: BROMO(ALPHA-)-GAMMA-BUTYROLACTONE;A-BROMO-GAMMA-BUTYROLACTONE;A-BROMO-G-BUTYROLACTONE;AKOS 23;ALPHA-BROMO-GAMMA-BUTYROLACETONE;ALPHA-BROMO-GAMMA-BUTYROLACTONE;2-BROMO-GAMMA-BUTYROLACTONE;2-BROMO-Y-BUTYROLACTONE
• CAS NO: 5061-21-2
• Molecular Formula: C₄H₅BrO₂
• Molecular Weight: 164.99
• EINECS: 225-764-4
• Product Categories: Pharmaceutical Intermediates;Heterocycles;Miscellaneous Reagents
• Mol File: 5061-21-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 138 °C6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: pale yellow liquid
• Density: 1.786 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: n20/D 1.508(lit.)
• Storage Temp.: 2-8°C
• Solubility: Acetone, Chloroform, Ethyl Acetate, Methanol
• Sensitive: Moisture Sensitive/Lachrymatory
• BRN: 107800
• CAS DataBase Reference: 2-Bromo-4-butanolide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-butanolide(5061-21-2)
• EPA Substance Registry System: 2-Bromo-4-butanolide(5061-21-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2810
• WGK Germany: 3
• F: 21
• TSCA: Yes
• Hazardous Substances Data: 5061-21-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Liquid

Uses

Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.

InChI:InChI=1/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2/t3-/m0/s1

Upstream product

• 96-48-0 4-butanolide 
• 63164-16-9 2,4-dibromo-butyric acid 
• 6305-38-0 α-amino-γ-butyrolactone hydrobromide 
• 52412-07-4 2,4-dibromo-butyryl bromide 

Downstream Products

• 42473-02-9 2-(2-oxotetrahydrofuran-3-yl)isoindolin-1,3-dione 
• 31332-88-4 (S)-3-(N-benzyloxycarbonylamino)tetrahydrofuran-2-one 
• 1192-20-7 2-aminobutyrolactone 
• 13602-48-7 3-benzoylamino-dihydro-furan-2-one 
• 101785-30-2 α-Benzylamino-γ-hydroxy-N-benzyl-butyramid 
• 77694-18-9 3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-dihydro-furan-2-one; hydrochloride 
• 35998-30-2 3-(phenylsulfanyl)-3,4-dihydrofuran-2-one 
• 91017-15-1 2-Cyclohexylamino-4-hydroxy-buttersaeure 
• 93189-96-9 α-cyclohexylamino-γ-hydroxybutyric acid cyclohexylamide 
• 169894-59-1 3-(4-phenylpiperazin-1-yl)-tetrahydrofuran-2-one 
• 169894-60-4 3-(4-benzylpiperazine)-tetrahydrofuran-2-one 
• 172883-56-6 (R,S)-3-(4-benzylpiperidin-1-yl)dihydrofuran-2(3H)-one 
• 96-48-0 4-butanolide 
• 10491-63-1 3-allyldihydrofuran-2-one 

Relevant articles and documents

Preparation method of DL-hydroxy selenomethionine

The invention belongs to the field of preparation of organic compounds. The invention provides a preparation method of DL-hydroxy selenomethionine. The method is characterized in that gamma-butyrolactone is used as a raw material, alpha-hydroxyl-gamma-butyrolactone is synthesized through alpha-bromination and hydroxylation, and then the alpha-hydroxyl-gamma-butyrolactone reacts with sodium methyl selenol to obtain the DL-hydroxyl selenomethionine. The method has the advantages of easily available raw materials, mild reaction conditions and low cost, and is suitable for large-scale preparation of DL-hydroxyselenomethionine.

Synthetic method for glufosinate ammonium

The invention relates to a synthetic method for glufosinate ammonium. The synthetic method comprises the following steps: single-bromine substitution, amination, amino protection, chlorination ring opening, Arbuzov reaction and acidizing hydrolysis ammoniation; the single-bromine substitution means triggering alpha-site single-bromine substitution betweengamma-butyrolactone I and bromine under theexistence of catalyst and performing reduced pressure distillation, thereby acquiring a pure intermediate II alpha-bromine-gamma-butyrolactone; phosphorus tribromide is served as the catalyst; amination means triggering amination reaction between alpha-bromine-gamma-butyrolactone II and ammonium hydroxide, and then adding hydrochloric acid and reflowing, thereby acquiring an intermediate IIIalpha-amino-gamma-butyrolactone hydrochloride. The invention has the beneficial effects: 1) low-costgamma-butyrolactone is taken as a raw material, is subjected to single-bromine substitution with bromineand then is subjected to amination reaction with ammonium hydroxide; the adopted raw materials are low-cost and easily acquired; reaction conditions are mild; operation is simple and convenient; safety is high; amplifying production is feasible; reaction yield is high; product purity is high; cost is greatly lowered; the synthetic method is suitable for industrial production.

Process for treating homoserin compounds

The present invention relates to the preparation of a useful compound which can be used as an intermediate product for preparing an important compound in the industrial field from a homoserine-based compound and provides a process for treating a homoserine-based compound, capable of simply mass producing a useful compound from a homoserine-based compound with excellent efficiency.(AA) Homoserine-based compound(BB) Product(CC) GBL derivative(DD) Halo-GBL(EE, FF, GG) GBL puranone(HH) Puranone(II) Dialkyl succinate(JJ) Step 1(KK) Step 2(LL) Step 3(MM) Step 4(NN) Step 5(OO) Step 6(PP) Step 7COPYRIGHT KIPO 2016