Tetrakis(4-fluorophenyl)ethane-1,2-diol

Base Information

• Chemical Name: Tetrakis(4-fluorophenyl)ethane-1,2-diol
• CAS No.: 424-82-8
• Molecular Formula: C26H18F4O2
• Molecular Weight: 438.421
• DSSTox Substance ID: DTXSID60570658
• Nikkaji Number: J718.907I
• Wikidata: Q82458178
• Mol file: 424-82-8.mol

Synonyms:424-82-8;Tetrakis(4-fluorophenyl)ethane-1,2-diol;SCHEMBL11598682;DTXSID60570658

Chemical Property of Tetrakis(4-fluorophenyl)ethane-1,2-diol

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 438.12429246
• Heavy Atom Count: 32
• Complexity: 489

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)F)(C(C3=CC=C(C=C3)F)(C4=CC=C(C=C4)F)O)O)F

Technology Process of Tetrakis(4-fluorophenyl)ethane-1,2-diol

There total 5 articles about Tetrakis(4-fluorophenyl)ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-Difluorobenzophenone (345-92-6) → 1,1,2,2-tetrakis-(4-fluorophenyl)-ethane-1,2-diol (424-82-8)

Guidance literature:

With CdS(x)Se(1-x) x:0-1;; para-thiocresol; In hexane; for 22h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.0c02627

Reference yield: 72.0%

4,4'-Difluorobenzophenone (345-92-6) → 4,4'-difluorobenzhydryl alcohol (365-24-2) + 1,1,2,2-tetrakis-(4-fluorophenyl)-ethane-1,2-diol (424-82-8)

Guidance literature:

4,4'-Difluorobenzophenone; With formic acid; In acetonitrile; at 25 ℃; for 0.0833333h;

In acetonitrile; at 25 ℃; for 6h; Electrochemical reaction;

DOI:10.1002/cjoc.202100508

Reference yield: 36.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + 4,4'-Difluorobenzophenone (345-92-6) → 1,1,2,2-tetrakis-(4-fluorophenyl)-ethane-1,2-diol (424-82-8) + C22H17F5O2 + meso-2,3-Di-(p-trifluormethyl-phenyl)-2,3-butandiol (192198-90-6)

Guidance literature:

With hydrazine hydrate; In acetonitrile; at 25 ℃; for 24h; Overall yield = 75 percentSpectr.; UV-irradiation; Inert atmosphere;

DOI:10.1039/c9sc03737c

upstream raw materials:

acetic acid

4,4'-Difluorobenzophenone

isopropyl alcohol

1,1-dichloro-2,2-bis-(4-fluoro-phenyl)-ethene

Downstream raw materials:

tetrakis-(4-fluoro-phenyl)-ethanone

Refernces

• 1、 Jo, Junhyuk,Kim, Seonyul,Choi, Jun-Ho,Chung, Won-Jin. "A convenient pinacol coupling of diaryl ketones with B2pin2viapyridine catalysis". supporting information. p. 1360 - 1363. Retrieved 2021/02/22.
• 2、 Chen, Gong,Qiao, Tianjiao,Wang, Yaxin,Zhang, Jian,Zhao, Jianyou. "Tunable System for Electrochemical Reduction of Ketones and Phthalimides". supporting information. p. 3297 - 3302. Retrieved 2021/10/14.