345-92-6Relevant articles and documents
Zwitterion-induced organic-metal hybrid catalysis in aerobic oxidation
Hu, Rong-Bin,Lam, Ying-Pong,Ng, Wing-Hin,Wong, Chun-Yuen,Yeung, Ying-Yeung
, p. 3498 - 3506 (2021/04/07)
In many metal catalyses, the traditional strategy of removing chloride ions is to add silver salts via anion exchange to obtain highly active catalysts. Herein, we reported an alternative strategy of removing chloride anions from ruthenium trichloride using an organic [P+-N-] zwitterionic compound via multiple hydrogen bond interactions. The resultant organic-metal hybrid catalytic system has successfully been applied to the aerobic oxidation of alcohols, tetrahydroquinolines, and indolines under mild conditions. The performance of zwitterion is far superior to that of many other common Lewis bases or Br?nsted bases. Mechanistic studies revealed that the zwitterion triggers the dissociation of chloride from ruthenium trichloride via nonclassical hydrogen bond interaction. Preliminary studies show that the zwitterion is applicable to catalytic transfer semi-hydrogenation.
4,4 ’ - Difluorobenzophenone and preparation method and application thereof
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Paragraph 0057-0099, (2021/11/21)
The 4, 4 ’ difluorobenzophenone and the preparation method thereof comprise: mixing a molecular sieve and hydrogen peroxide and with fluorobenzaldehyde to form a mixed solution, oxidizing fluorobenzaldehyde into p-fluorobenzoic acid, wherein the molecular sieve is a catalyst. Hydrochloric acid and zinc chloride are added to the mixed solution to generate p-fluorobenzoyl chloride under the condition that the molecular sieve is used as a catalyst. Fluorobenzene was added to the mixed solution containing the p-fluorobenzoyl chloride to obtain the 4, 4 ’ - difluorobenzophenone. Thus, the synthetic method has the following advantages: 4, the yield of 4 ’ - difluorobenzophenone is not lower 98%, the purity is not lower than 99.999%, and the purity makes it available for preparation of medical grade polyether ether ketone. Reaction conditions are easy to control, and the risk of explosion is reduced to a certain extent.
Preparation method of benzophenone derivative
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Paragraph 0054-0059, (2021/06/22)
The invention provides a preparation method of a benzophenone derivative. The preparation method comprises the following step: subjecting a benzoic acid compound as shown in a formula I, a trichlorotoluene compound as shown in a formula II and a benzene compound as shown in a formula III to reacting under the catalysis of Fe2O3 to obtain the benzophenone derivative. According to the preparation method provided by the invention, the metal oxide Fe2O3 with higher stability and safety is used as a catalyst, so corrosion of materials to equipment is avoided, and the preparation method is more environment-friendly; according to the preparation method, the target product is obtained through one-step reaction, reaction conditions are mild, and a process is simple; and the main byproduct benzoic acid compound generated by the reaction can be recycled by washing, extracting and desolventizing in post-treatment, and then is used as a reaction raw material for preparing the benzophenone derivative again, so wastewater treatment cost is reduced, and resources are fully utilized.