118559-07-2

Basic information

• Product Name: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate
• Synonyms: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate
• CAS NO: 118559-07-2
• Molecular Weight: 348.39
• Mol File: 118559-07-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate(118559-07-2)
• EPA Substance Registry System: ethyl 3,3-bis(4-fluorophenyl)-3-hydroxy-2-(1-methylethyl)-propionate(118559-07-2)

Safety Data

• Hazardous Substances Data: 118559-07-2(Hazardous Substances Data)

Upstream product

• 108-64-5 Ethyl isovalerate 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 118559-14-1 (E)-(3R,5R)-8-[Bis-(4-fluoro-phenyl)-methylene]-3,5-dihydroxy-9-methyl-dec-6-enoic acid ethyl ester 
• 118559-14-1 (E)-(3S,5R)-8-[Bis-(4-fluoro-phenyl)-methylene]-3,5-dihydroxy-9-methyl-dec-6-enoic acid ethyl ester 
• 120925-84-0 (E)-8-[Bis-(4-fluoro-phenyl)-methylene]-5-hydroxy-9-methyl-3-oxo-dec-6-enoic acid ethyl ester 
• 118559-11-8 (E)-4-[Bis-(4-fluoro-phenyl)-methylene]-5-methyl-hex-2-enenitrile 
• 120846-54-0 5,5-bis(4-fluorophenyl)-4-(1-methylethyl)-2,4-pentadienal 
• 118559-10-7 3,3-bis(4-fluorophenyl)-2-(1-methylethyl)propenal 
• 118581-22-9 Sodium; (E)-(3S,5R)-8-[bis-(4-fluoro-phenyl)-methylene]-3,5-dihydroxy-9-methyl-dec-6-enoate 
• 118559-08-3 ethyl 3,3-bis(4-fluorophenyl)-2-(1-methylethyl)propenoate 
• 146579-00-2 2-di(4-fluorophenyl)methylidene-3-methylbutyl(diphenyl)phosphine oxide 
• 118559-09-4 2-di(4-fluorophenyl)methylene-3-methyl-1-butanol 

Relevant articles and documents

Synthesis of artificial HMG-CoA reductase inhibitors based on the olefination strategy

Synthetic methods were studied for optically active 6-oxo-3,5-isopropylidenedioxyhexanoate esters (4), which could be used as a key precursor of various kinds of artificial analogs of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. An enantiomer (+)-4 was prepared by asymmetric reduction of β,δ-diketo esters derived from the Taber's alcohol or L-tartrate followed by a series of chemical transformations, and the desired enantiomer (-)-4 was prepared by the same asymmetric reduction starting from D-tartrate. The key intermediate (-)-4 was finally converted into a highly potent HMG-CoA reductase inhibitor, NK-104.

SYNTHESIS OF A NOVEL HMG-COA REDUCTASE INHIBITOR

The synthesis of a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor starting from 4,4'-difluorobenzophenone is described.