N-(4-methoxyphenyl)methanesulfonamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)methanesulfonamide
• CAS No.: 4284-48-4
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• DSSTox Substance ID: DTXSID80355085
• Nikkaji Number: J1.025.452C
• Wikidata: Q82133715
• Mol file: 4284-48-4.mol

Synonyms:N-(4-methoxyphenyl)methanesulfonamide;4284-48-4;Methanesulfonamide, N-(4-methoxyphenyl)-;Bionet2_000453;Cambridge id 5256859;Oprea1_535471;Oprea1_801515;SCHEMBL171658;DTXSID80355085;HMS1365E13;MFCD00583104;STK395877;AKOS000673213;N-(4-methoxyphenyl)methanesulfon-amide;CS-0302860;7N-070;EN300-741079

Chemical Property of N-(4-methoxyphenyl)methanesulfonamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 201.04596439
• Heavy Atom Count: 13
• Complexity: 237

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NS(=O)(=O)C

Technology Process of N-(4-methoxyphenyl)methanesulfonamide

There total 10 articles about N-(4-methoxyphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-aniline (104-94-9) + methanesulfonyl chloride (124-63-0) → N-(4-methoxyphenyl)methanesulfonamide (4284-48-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 26.5h;

DOI:10.1002/ejoc.201800962

Reference yield: 97.0%

4-methoxy-aniline (104-94-9) + Methanesulfonic anhydride (7143-01-3) → N-(4-methoxyphenyl)methanesulfonamide (4284-48-4)

Guidance literature:

4-methoxy-aniline; Methanesulfonic anhydride; With triethylamine; In dichloromethane; at 20 ℃;

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1016/j.tetlet.2008.08.054

Reference yield: 96.0%

1-bromo-4-methoxy-benzene (104-92-7) + methanesulfonamide (3144-09-0) → N-(4-methoxyphenyl)methanesulfonamide (4284-48-4)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; tert-butyl XPhos; In 2-methyltetrahydrofuran; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol200660s

upstream raw materials:

4-methoxy-aniline

methanesulfonyl chloride

1-methanesulfonyloxy-1,2,3-benzotriazole

4-methoxy-benzaldehyde

Downstream raw materials:

4-methoxy-aniline

N-ethyl-N-(4-methoxyphenyl)methanesulfonamide

Refernces

• 1、 Chaturvedi, Jagriti,Haldar, Chabush,Bisht, Ranjana,Pandey, Gajanan,Chattopadhyay, Buddhadeb. "Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction". supporting information. p. 7604 - 7611. Retrieved 2021/05/26.
• 2、 Gajare, Shivanand,Jagadale, Megha,Naikwade, Altafhusen,Bansode, Prakash,Rashinkar, Gajanan. "Facile Chan-Lam coupling using ferrocene tethered N-heterocyclic carbene-copper complex anchored on graphene". . . Retrieved 2019/04/08.