(1-aminocyclohexyl)methanol

Base Information

• Chemical Name: (1-aminocyclohexyl)methanol
• CAS No.: 4313-56-8
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2922199090
• Mol file: 4313-56-8.mol

Synonyms:1-Amino-1-(hydroxyethyl)cyclohexane;1-(hydroxymethyl)-cyclohexyl amine;1-(Hydroxymethyl)cyclohexan-1-amine;1-amino-1-cyclohexylmethanol;1-aminocyclohexane-1-methanol;(1-Aminocyclohex-1-yl)methanol;1-amino-1-hydroxymethyl-cyclohexane;

Chemical Property of (1-aminocyclohexyl)methanol

Chemical Property:

• Melting Point: 34-38°C
• PSA: 46.25000
• LogP: 1.34060

Purity/Quality:

98% ^*data from raw suppliers

(1-?Aminocyclohexyl)?methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

• Uses: (1-?Aminocyclohexyl)?methanol is used in the synthesis of Fsp3-rich, bis-spirocyclic-based compound libraries.

Technology Process of (1-aminocyclohexyl)methanol

There total 9 articles about (1-aminocyclohexyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-aminocyclohexane carboxylic acid (2756-85-6) → (1-aminocyclohexyl)methanol (4313-56-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 99.0%

methyl 1-aminocyclohexanecarboxylate (4507-57-7) → (1-aminocyclohexyl)methanol (4313-56-8)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 0 - 110 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acscombsci.6b00005

Reference yield:

(1-nitrocyclohexyl)methanol (3719-52-6) → (1-aminocyclohexyl)methanol (4313-56-8)

Guidance literature:

With methanol; nickel; at 65 - 125 ℃; under 30891.3 Torr; Hydrogenation;

DOI:10.1007/BF02962204

upstream raw materials:

(1-nitrocyclohexyl)methanol

1-amino-1-cyclohexanecarboxylic acid ethyl ester

1-aminocyclohexane carboxylic acid

1-amino-1-cyclohexane carboxylic acid hydrochloride

Downstream raw materials:

1-benzoyl-2-phenyl-3-oxa-1-aza-spiro[4.5]decane

1,1'-bis(dithiomethyl)cyclohexanamine

1-(bromomethyl)cyclohexylammonium bromide

2-Phenyl-oxazolidine-4-spiro-cyclohexane

Refernces

• 1、 -. "PROCESS FOR PRODUCING SUBSTITUTED AMINO ALCOHOLS". Page/Page column 30. . Retrieved 2020/06/01.
• 2、 Stotani, Silvia,Lorenz, Christoph,Winkler, Matthias,Medda, Federico,Picazo, Edwige,Ortega Martinez, Raquel,Karawajczyk, Anna,Sanchez-Quesada, Jorge,Giordanetto, Fabrizio. "Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening". . p. 330 - 336. Retrieved 2016/07/06.