2-methylidenebutan-1-ol

Base Information

• Chemical Name: 2-methylidenebutan-1-ol
• CAS No.: 4435-54-5
• Molecular Formula: C5H10O
• Molecular Weight: 86.1338
• Hs Code.: 2905290000
• Mol file: 4435-54-5.mol

Synonyms:Hexanedioic acid,2-ethyl;Ethyladipate;2-Ethyladipate;2-Ethylhexanedioicacid;2-Ethyl-2-propen-1-ol;2-Ethyladipinsaeure;Ethyladipic acid;2-Ethyl-hexandisaeure;2-ethylallylalcohol = 2=Aethylallylalkohol;2-ethyl-adipic acid;2-methylene-butan-1-ol;2-Aethyl-adipinsaeure;2-ethylallyl alcohol;2-ethyl-1,6-hexanedioic acid;

Chemical Property of 2-methylidenebutan-1-ol

Chemical Property:

• Vapor Pressure: 3.38mmHg at 25°C
• Boiling Point: 135.1oC at 760 mmHg
• PKA: 14.80±0.10(Predicted)
• Flash Point: 45.7oC
• PSA: 20.23000
• Density: 0.832g/cm3
• LogP: 0.94490
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Ethyl-2-propen-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Ethyl-2-propen-1-ol is an intermediate in the synthesis of 2-(Chloromethyl)-1-butene (C368570). 2-(Chloromethyl)-1-butene?is a useful reagent for palladium(II)-catalyzed intramolecular tandem aminoalkylation. It can also be used to prepare?(±)-Stemonamine and (±)-Cephalotaxine.

Technology Process of 2-methylidenebutan-1-ol

There total 16 articles about 2-methylidenebutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethylacrolein (922-63-4) → 2-Methylene-1-butanol (4435-54-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1021/jacs.5b03732

Reference yield: 65.0%

ethylmagnesium bromide (925-90-6) + propargyl alcohol (107-19-7) → 2-Methylene-1-butanol (4435-54-5)

Guidance literature:

With copper(l) iodide; In diethyl ether; at -78 - 20 ℃; for 12.5h;

DOI:10.1002/anie.202008770

Reference yield: 55.0%

propargyl alcohol (107-19-7) → 2-Methylene-1-butanol (4435-54-5)

Guidance literature:

With copper(l) iodide; In diethyl ether; at -10 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201100916

upstream raw materials:

ethylacrolein

formaldehyd

sodium butanolate

2-(chloromethyl)-1-butene

Downstream raw materials:

2-Methylbutyraldehyde

2-methyl-but-1-en-1-ol

ethylacrolein

formic acid

Refernces

• 1、 -. "ODORANTS AND COMPOSITIONS COMPRISING ODORANTS". Page/Page column 24-25. . Retrieved 2021/10/22.
• 2、 Fu, Aixiao,Jiang, Shifeng,Liu, Qiang,Liu, Xiaoran,Liu, Xiuyun,Mu, Xindong,Sun, Mengqing,Wang, Xicheng,Xu, Guoqiang,Zhao, Lingling. "Tailoring Interfacial Lewis Acid-Basic Pair on ZnO/4Mg1ZrOx Allows Dehydrogenative α-Methylenation of Alcohols with Methanol to Allylic Alcohols". . . Retrieved 2020/10/07.