5-HYDROXYMETHYLINDANE

Base Information

• Chemical Name: 5-HYDROXYMETHYLINDANE
• CAS No.: 51632-06-5
• Molecular Formula: C10H12 O
• Molecular Weight: 148.205
• Hs Code.: 2906299090
• Mol file: 51632-06-5.mol

Synonyms:(2,3-Dihydro-1H-inden-5-yl)methanol;5-(Hydroxymethyl)indane; 5-Indanylmethanol; NSC 317014

Chemical Property of 5-HYDROXYMETHYLINDANE

Chemical Property:

• Vapor Pressure: 0.00214mmHg at 25°C
• Melting Point: 73.5-74.5 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 277.7°C at 760 mmHg
• PKA: 14.50±0.10(Predicted)
• Flash Point: 131.2°C
• PSA: 20.23000
• Density: 1.119g/cm³
• LogP: 1.66760

Purity/Quality:

99%min ^*data from raw suppliers

1H-INDENE-5-METHANOL,2,3-DIHYDRO 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXYMETHYLINDANE

There total 12 articles about 5-HYDROXYMETHYLINDANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

indan-5-carbaldehyde (30084-91-4) → (2,3-dihydro-1H-inden-5-yl)methanol (51632-06-5)

Guidance literature:

indan-5-carbaldehyde; With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.5h;

With hydrogenchloride; In water; pH=2;

Reference yield: 94.0%

methyl 5-indanecarboxylate (86031-43-8) → (2,3-dihydro-1H-inden-5-yl)methanol (51632-06-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 12h; Heating;

DOI:10.1007/BF00809674

Reference yield: 90.0%

indan-5-carboxylic acid (65898-38-6) → (2,3-dihydro-1H-inden-5-yl)methanol (51632-06-5)

Guidance literature:

indan-5-carboxylic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

Indancarbonsaeure-(5)-ethylester

methyl 5-indanecarboxylate

hepta-1,6-diyne

propargyl alcohol

Downstream raw materials:

5-(bromomethyl)-2,3-dihydro-1H-indene

3-Methyl-2-p-tolyl-butyric acid indan-5-ylmethyl ester

indan-5-ylmethylamine

4-(indan-5-ylmethoxy)benzaldehyde

Refernces

• 1、 Wang, Youxin,Di, Hongxia,Chen, Feifei,Xu, Yong,Xiao, Qiang,Wang, Xuehai,Wei, Hanwen,Lu, Yanli,Zhang, Lingling,Zhu, Jin,Lan, Lefu,Li, Jian. "Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN)". . p. 4831 - 4848. Retrieved 2016/06/13.
• 2、 -. "NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS". Page/Page column 60. . Retrieved 2009/10/22.