1-Cyano-3-isopropylguanidine

Base Information

• Chemical Name: 1-Cyano-3-isopropylguanidine
• CAS No.: 44830-55-9
• Molecular Formula: C5H10N4
• Molecular Weight: 126.161
• Hs Code.: 2926909090
• Mol file: 44830-55-9.mol

Synonyms:1-cyano-2-propan-2-ylguanidine;Proguanil Related Compound A;

Chemical Property of 1-Cyano-3-isopropylguanidine

Chemical Property:

• Melting Point: 87-89°C
• PSA: 71.70000
• LogP: 0.87138
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1-Cyano-3-isopropylguanidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Cyano-3-isopropylguanidine (Proguanil EP Impurity A) is an intermediate commonly used for the synthesis of guanide derivatives.An Impurity in the synthesis of Chlorguanide (C329500). 1-Cyano-3-isopropylguanidine is an intermediate commonly used for the synthesis of guanide derivatives.

Technology Process of 1-Cyano-3-isopropylguanidine

There total 7 articles about 1-Cyano-3-isopropylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ 3-cyano-1-isopropylguanidine (44830-55-9)

Guidance literature:

With diethyl ether; In butan-1-ol; Reflux;

Reference yield:

N-cyano-N'-isopropyl-S-methyl-isothiourea (5848-27-1) → 3-cyano-1-isopropylguanidine (44830-55-9)

Guidance literature:

With ethanol; ammonia; at 100 ℃;

Reference yield:

isopropylamine hydrochloride (15572-56-2) + sodium dicyanamide (1934-75-4) → 3-cyano-1-isopropylguanidine (44830-55-9)

Guidance literature:

In butan-1-ol; for 4h; Heating;

DOI:10.1111/j.2042-7158.1980.tb12989.x

upstream raw materials:

N-cyano-N'-isopropyl-S-methyl-isothiourea

isopropylamine hydrochloride

sodium dicyanamide

ammonia

Downstream raw materials:

1-isopropyl-5-(4-fluorophenyl)biguanide

1-(4-fluoro-phenyl)-5-isopropyl-biguanide; hydrochloride

proguanil

1-isopropyl-5-phenyl-biguanide

Refernces

• 1、 Plaut,Meakin,Davies. "On the anomalous sorption behaviour of chlorhexidine with poly(2-hydroxyethyl methacrylate)". . p. 525 - 532. Retrieved 2007/10/02.