1,2,3-Indolizinetricarboxylic acid, trimethyl ester

Base Information

• Chemical Name: 1,2,3-Indolizinetricarboxylic acid, trimethyl ester
• CAS No.: 4491-43-4
• Molecular Formula: C14H13NO6
• Molecular Weight: 291.26
• Mol file: 4491-43-4.mol

Synonyms:

Chemical Property of 1,2,3-Indolizinetricarboxylic acid, trimethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3-Indolizinetricarboxylic acid, trimethyl ester

There total 1 articles about 1,2,3-Indolizinetricarboxylic acid, trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4H-Chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester (1101-39-9) → Dimethyl ether (115-10-6,157621-61-9) + acetic acid methyl ester (79-20-9) + 3-(Methoxycarbonylmethyl)-1,2-indolizindicarbonsaeure-dimethylester (18782-33-7) + 1,2,3-Indolizintricarbonsaeure-trimethylester (4491-43-4) + 1,2-Indolizindicarbonsaeure-dimethylester (16959-60-7) + 2,3-Indolizindicarbonsaeure-dimethylester (82884-77-3)

Guidance literature:

at 220 ℃; for 10h; Mechanism;

Reference yield:

1,2,3-Indolizintricarbonsaeure-trimethylester (4491-43-4) → indolizidine (13618-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated aqueous KOH / Erwaermen des Reaktionsprodukts mit wss. HCl

2: lime/chalk/

3: platinum; acetic acid / Hydrogenation

With potassium hydroxide; methyllithium; acetic acid; platinum; calcium carbonate;

Reference yield:

1,2,3-Indolizintricarbonsaeure-trimethylester (4491-43-4) → indolizine-2-carboxylic acid (3189-48-8)

Guidance literature:

With potassium hydroxide; Erwaermen des Reaktionsprodukts mit wss. HCl;

DOI:10.1021/jo50013a010

upstream raw materials:

4H-Chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester

Downstream raw materials:

indolizine-2-carboxylic acid

indolizidine

Refernces