tetramethyl 4H-quinolizine-1,2,3,4-tetracarboxylate

Base Information

• Chemical Name: tetramethyl 4H-quinolizine-1,2,3,4-tetracarboxylate
• CAS No.: 1101-39-9
• Molecular Formula: C17H17 N O8
• Molecular Weight: 363.324
• Mol file: 1101-39-9.mol

Synonyms:4H-Quinolizine-1,2,3,4-tetracarboxylicacid, tetramethyl ester (7CI,8CI,9CI); NSC 519796

Chemical Property of tetramethyl 4H-quinolizine-1,2,3,4-tetracarboxylate

Chemical Property:

• Vapor Pressure: 4.74E-10mmHg at 25°C
• Boiling Point: 497.9°Cat760mmHg
• Flash Point: 254.9°C
• Density: 1.38g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tetramethyl 4H-quinolizine-1,2,3,4-tetracarboxylate

There total 8 articles about tetramethyl 4H-quinolizine-1,2,3,4-tetracarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

pyridine (110-86-1) + diazoacetic acid ethyl ester (623-73-4) + dimethyl acetylenedicarboxylate (762-42-5) → 4H-Chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester (1101-39-9)

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; In dichloromethane; at 18 - 22 ℃; for 16h;

DOI:10.1021/acs.orglett.7b03252

Reference yield: 55.0%

2-(trimethylsilyl)pyridine (13737-04-7) + dimethyl acetylenedicarboxylate (762-42-5) → 4H-Chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester (1101-39-9) + 6-(Trimethylsilyl)-9aH-chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester (87361-41-9)

Guidance literature:

In diethyl ether; at -20 ℃; for 480h;

Reference yield:

pyridine (110-86-1) + dimethyl acetylenedicarboxylate (762-42-5) → tetramethyl 9aH-quinolizine-1,2,3,4-tetracarboxylate (101878-66-4) + 4H-Chinolizin-1,2,3,4-tetracarbonsaeure-tetramethylester (1101-39-9)

Guidance literature:

With diethyl ether;

upstream raw materials:

pyridine

diethyl ether

dimethyl acetylenedicarboxylate

methanol

Downstream raw materials:

Dimethyl ether

acetic acid methyl ester

3-(Methoxycarbonylmethyl)-1,2-indolizindicarbonsaeure-dimethylester

1,2,3-Indolizintricarbonsaeure-trimethylester

Refernces

• 1、 Adib, Mehdi,Yavari, Hossine,Mollahosseini, Mehdi. "Efficient one-pot synthesis of 2-oxo-1,9a-dihydro-2H-pyrido[1,2-a] pyrimidine derivatives". . p. 1803 - 1805. Retrieved 2004.
• 2、 Birkofer, Leonhard,Wahle, Bernd. "C-Silyl Derivatives of Quinolizines". . p. 2564 - 2573. Retrieved 2007/10/02.