BOC-L-SELENOMETHIONINE

Base Information

• Chemical Name: BOC-L-SELENOMETHIONINE
• CAS No.: 45172-44-9
• Molecular Formula: C10H19NO4Se
• Molecular Weight: 296.225
• Hs Code.: 2924199090
• Mol file: 45172-44-9.mol

Synonyms:Boc-4,5-dehydro-L-leucine dicyclohexylamine salt;Boc-4,5-dehydro-Leu-OH (dicyclohexylammonium) salt;Boc-4,5-dehydro-L-leucine (dicyclohexylammonium) salt;N-t-butyloxycarbonyl-L-selenomethionine;N-t-butyloxycarbonyl-4,5-dehydro-L-leucine dicyclohexylammonium salt;(2S)-2-[(tert-butoxycarbonyl)amino]-4-methylpent-4-enoic acid;(S)-2-(Boc-amino)-4-methyl-4-pentenoic acid dicyclohexylamine salt;Boc-4,5-dehydro-Leu-OH dicyclohexylamine salt;

Chemical Property of BOC-L-SELENOMETHIONINE

Chemical Property:

• PSA: 79.12000
• LogP: 1.72940

Purity/Quality:

98%min ^*data from raw suppliers

Boc-L-selenomethionine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-SELENOMETHIONINE

There total 5 articles about BOC-L-SELENOMETHIONINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-benzyl N-t-butoxycarbonylselenomethioninate (109276-72-4) → N-Boc-L-selenomethionine (45172-44-9,1219410-27-1)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88049-2

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + Seleno-L-methionine (3211-76-5) → N-Boc-L-selenomethionine (45172-44-9,1219410-27-1)

Guidance literature:

Seleno-L-methionine; With sodium hydrogencarbonate; In 1,4-dioxane; water; for 0.333333h; Cooling with ice;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 ℃; for 13h; Cooling with ice;

Reference yield:

Boc-Glu-OBn (30924-93-7) → N-Boc-L-selenomethionine (45172-44-9,1219410-27-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutylchloroformate, 2.) triethylamine / 1.) THF, -15 deg C, 5 min, 2.) THF, -15 deg C, 20 min

2: tetrahydrofuran / 0.33 h / Irradiation

3: 100 percent / NaOH / dioxane; H₂O / 0.5 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1016/S0040-4020(01)88049-2

upstream raw materials:

L-benzyl N-t-butoxycarbonylselenomethioninate

di-tert-butyl dicarbonate

Seleno-L-methionine

Boc-Glu-OBn

Refernces

• 1、 Li, Yang,Feng, Ling,Song, Zhi-Fang,Li, Hai-Bei,Huai, Qi-Yong. "Synthesis and anticancer activities of glycyrrhetinic acid derivatives". . . Retrieved 2016/05/09.
• 2、 -. "Novel Dipeptides incorporating selenoamino acids with enhanced bioavailability- Synthesis, pharmaceutical and cosmeceutical applications thereof". Page/Page column 11. . Retrieved 2010/11/29.