Octadecanedioyl dichloride

Base Information

• Chemical Name: Octadecanedioyl dichloride
• CAS No.: 45270-18-6
• Molecular Formula: C18H32Cl2O2
• Molecular Weight: 351.357
• Mol file: 45270-18-6.mol

Synonyms:

Chemical Property of Octadecanedioyl dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Octadecanedioyl dichloride

There total 6 articles about Octadecanedioyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

octadecanedioic acid (871-70-5) → 1,18-octadecanedioyl dichloride (45270-18-6)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1021/ja00171a026

Reference yield:

Adipic acid (124-04-9) → 1,18-octadecanedioyl dichloride (45270-18-6)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 1 h / 50 °C

2: 1.) triethylamine; 2.) 20percent HCl / 1.) chloroform, 35 deg C, 5 h; 2.) chloroform, reflux, 5 h

3: sodium hydroxide / ethanol / 1 h / Heating

4: 1.) hydrazine hydrate; 2.) potassium hydroxide / 1.) triethanolamine, 130 deg C; reflux, 4 h; 2.) triethanolamine, 200 deg C, 9 h

5: thionyl chloride / 1 h / 50 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; thionyl chloride; hydrazine hydrate; triethylamine; In ethanol;

DOI:10.1021/ja00209a032

Reference yield:

1,6-Bis(2-oxocyclohexyl)-1,6-hexandion (14208-97-0) → 1,18-octadecanedioyl dichloride (45270-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 1 h / Heating

2: 1.) hydrazine hydrate; 2.) potassium hydroxide / 1.) triethanolamine, 130 deg C; reflux, 4 h; 2.) triethanolamine, 200 deg C, 9 h

3: thionyl chloride / 1 h / 50 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.1021/ja00209a032

upstream raw materials:

octadecanedioic acid

Adipic acid

1,6-Bis(2-oxocyclohexyl)-1,6-hexandion

Adipic acid dichloride

Downstream raw materials:

1,18-octadecane diamine

octadecanedioic acid tert-butyl ester-2,5-dioxopyrrolidin-1-yl ester

1,18-octadecanedioic acid mono-tert-butyl ester

bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} octadecanedioate

Refernces

• 1、 Tarkin-Tas, Eylem,Lange, Christopher A.,Mathias, Lon J.. "Hydrogen-bonded supramolecular polymers from derivatives of α-amino-ε-caprolactam: A bio-based material". . p. 2451 - 2460. Retrieved 2011.
• 2、 Akae, Yosuke,Koyama, Yasuhito,Sogawa, Hiromitsu,Hayashi, Yoshihiro,Kawauchi, Susumu,Kuwata, Shigeki,Takata, Toshikazu. "Structural Analysis and Inclusion Mechanism of Native and Permethylated α-Cyclodextrin-Based Rotaxanes Containing Alkylene Axles". supporting information. p. 5335 - 5341. Retrieved 2016/04/09.
• 3、 McRobb, Fiona M.,Crosby, Ian T.,Yuriev, Elizabeth,Lane, J. Robert,Capuano, Ben. "Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation". supporting information; experimental part. p. 1622 - 1634. Retrieved 2012/04/17.