OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER

Base Information

• Chemical Name: OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER
• CAS No.: 843666-40-0
• Molecular Formula: C22H42 O4
• Molecular Weight: 370.573
• Hs Code.: 2918990090
• Mol file: 843666-40-0.mol

Synonyms:Octadecanedioicacid, mono(1,1-dimethylethyl) ester (9CI)

Chemical Property of OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER

Chemical Property:

• Melting Point: 68 °C
• Boiling Point: 470.7±18.0 °C(Predicted)
• PKA: 4.78±0.10(Predicted)
• PSA: 63.60000
• Density: 0.950±0.06 g/cm3(Predicted)
• LogP: 6.65430
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.0% ^*data from raw suppliers

18-(tert-Butoxy)-18-oxooctadecanoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 18-(tert-Butoxy)-18-oxooctadecanoic Acid is used to engineer long-acting, potent exendin-4 based GLP-1 analog for microstructure-based transdermal delivery for glycemic control.

Technology Process of OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER

There total 17 articles about OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

octadecanedioic acid (871-70-5) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0)

Guidance literature:

In toluene; at 95 ℃; Inert atmosphere;

Reference yield: 72.0%

18-chloro-18-oxyoctadecanoic acid + tert-butyl alcohol (75-65-0) → 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0)

Guidance literature:

In dichloromethane;

Reference yield: 71.0%

octadecanedioic acid ditert-butyl ester → 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0)

Guidance literature:

With barium hydroxide octahydrate; In methanol; tert-butyl alcohol; at 28 - 30 ℃; for 20h; Large scale;

upstream raw materials:

octadecanedioic acid

N,N-dimethylformamide di-tert-butyl acetal

1,18-octadecanedioyl dichloride

tert-butyl alcohol

Downstream raw materials:

octadecanedioic acid tert-butyl ester-2,5-dioxopyrrolidin-1-yl ester

Refernces

• 1、 -. "Preparation method of long-chain alkyl diacid mono-tert-butyl ester". . . Retrieved 2021/06/13.
• 2、 Kjeldsen, Thomas B.,Hubálek, Franti?ek,Tagmose, Tina M.,Pridal, Lone,Refsgaard, Hanne H. F.,Porsgaard, Trine,Gram-Nielsen, Sanne,Hovgaard, Lars,Valore, Henrik,Münzel, Martin,Hj?rringgaard, Claudia U.,Jeppesen, Claus Bekker,Manfè, Valentina,Hoeg-Jensen, Thomas,Ludvigsen, Svend,Nielsen, Peter Kresten,Lautrup-Larsen, Inger,Stidsen, Carsten E.,Wulff, Erik M.,Garibay, Patrick W.,Kodra, János T.,Nishimura, Erica,Madsen, Peter. "Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320". . p. 616 - 628. Retrieved 2021/01/13.