2-Propynoic acid, 3-(2-furanyl)-

Base Information

• Chemical Name: 2-Propynoic acid, 3-(2-furanyl)-
• CAS No.: 4582-65-4
• Molecular Formula: C7H4O3
• Molecular Weight: 136.107
• Mol file: 4582-65-4.mol

Synonyms:

Chemical Property of 2-Propynoic acid, 3-(2-furanyl)-

Chemical Property:

• PSA: 50.44000
• LogP: 0.71570

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-(Furan-2-yl)prop-2-ynoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propynoic acid, 3-(2-furanyl)-

There total 5 articles about 2-Propynoic acid, 3-(2-furanyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromofuran (584-12-3) + Propiolic acid (471-25-0) → 3-(2'-furfuryl)propiolic acid (4582-65-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00952

Reference yield:

(5-bromo-[2]furyl)-propiolic acid (3199-47-1) → 3-(2'-furfuryl)propiolic acid (4582-65-4)

Guidance literature:

With ammonium hydroxide; zinc;

DOI:10.1021/ja01362a040

Reference yield:

ethyl 3-(furan-2-yl)prop-2-ynoate (38898-09-8) → 3-(2'-furfuryl)propiolic acid (4582-65-4)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In diethyl ether; water; for 120h; Yield given;

DOI:10.1039/P19940002461

upstream raw materials:

(5-bromo-[2]furyl)-propiolic acid

ethyl 3-(furan-2-yl)prop-2-ynoate

2-bromofuran

Propiolic acid

Downstream raw materials:

2-(2-(4-methoxyphenyl)ethynyl)furan

1-nitro-4-(2'-furfurylethynyl)benzene

1-(4-methoxyphenyl)-4-(2-furfuryl)buta-1,3-diyne

ethyl 5-(2-furyl)-3-oxo-2-triphenylphosphoranylidenepent-4-ynoate

Refernces

• 1、 Aitken, R. Alan,Seth, Shirley. "Flash Vacuum Pyrolysis of Stabilised Phosphorous Ylides. Part 4. Stepwise Construction of Terminal 1,3-Diynes, Conjugated Diacetylenic Esters and a Triacetylenic Ester". . p. 2461 - 2466. Retrieved 2007/10/02.