p-((Trimethylsilyl)oxy)benzaldehyde

Base Information

• Chemical Name: p-((Trimethylsilyl)oxy)benzaldehyde
• CAS No.: 1012-12-0
• Molecular Formula: C10H14O2Si
• Molecular Weight: 194.305
• Hs Code.: 2931900090
• European Community (EC) Number: 213-789-3
• DSSTox Substance ID: DTXSID70143771
• Nikkaji Number: J108.909I
• Wikidata: Q83007766
• Mol file: 1012-12-0.mol

Synonyms:1012-12-0;4-[(trimethylsilyl)oxy]benzaldehyde;4-(Trimethylsiloxy)Benzaldehyde;4-Trimethylsilyloxybenzaldehyde;4-((Trimethylsilyl)oxy)benzaldehyde;p-((Trimethylsilyl)oxy)benzaldehyde;4-(trimethylsilyloxy)benzaldehyde;4-Trimethylsiloxybenzaldehyde;Benzaldehyde, p-(trimethylsiloxy)-;Benzaldehyde, 4-[(trimethylsilyl)oxy]-;EINECS 213-789-3;MFCD00040723;4-Hydroxybenzaldehyde, TMS derivative;P-[(trimethylsilyl)oxy]benzaldehyde;(4-Formylphenoxy)trimethylsilane;Benzaldehyde, 4-hydroxy, TMS;SCHEMBL3438230;DTXSID70143771;4-(trimethyl silyloxy)benzaldehyde;BAA01212;AKOS006230430;AS-44229;SY041897;CS-0158134;FT-0617328;EN300-7360902

Chemical Property of p-((Trimethylsilyl)oxy)benzaldehyde

Chemical Property:

• Appearance/Colour: Light yellow powder
• Vapor Pressure: 0.0654mmHg at 25°C
• Refractive Index: 1.5180
• Boiling Point: 230.6 °C at 760 mmHg
• Flash Point: 77.6 °C
• PSA: 26.30000
• Density: 1.002 g/cm³
• LogP: 2.71280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 194.076306220
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

98% ^*data from raw suppliers

4-(Trimethylsilyloxy)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)OC1=CC=C(C=C1)C=O

Technology Process of p-((Trimethylsilyl)oxy)benzaldehyde

There total 8 articles about p-((Trimethylsilyl)oxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloro-trimethyl-silane (75-77-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(trimethylsiloxy)benzaldehyde (1012-12-0)

Guidance literature:

With triethylamine; In diethyl ether; 1 h, 20 deg C;

DOI:10.1002/jlac.198619861010

Reference yield: 95.0%

(4-(1,3-dithian-2-yl)phenoxy)trimethylsilane → 4-(trimethylsiloxy)benzaldehyde (1012-12-0)

Guidance literature:

With iodosylbenzene; In dichloromethane; at 20 ℃;

DOI:10.24820/ARK.5550190.P011.476

Reference yield: 75.0%

(4-trimethylsilanyloxy-phenyl)-acetic acid (79302-32-2) → 4-(trimethylsiloxy)benzaldehyde (1012-12-0)

Guidance literature:

With mercury(II) fluoride; oxygen; In acetonitrile; at 25 ℃; for 24h; Irradiation;

DOI:10.1016/j.tetlet.2006.01.082

upstream raw materials:

chloro-trimethyl-silane

4-hydroxy-benzaldehyde

N,O-bis-(trimethylsilyl)-acetamide

N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide

Downstream raw materials:

methyl 3-hydroxy-3-(p-hydroxyphenyl)propionate

GA-1

4-[hydroxy-(4-vinyl-phenyl)-methyl]-phenol

3-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-propionic acid benzyl ester

Refernces

• 1、 Du, Yunfei,Ouyang, Yaxin,Wang, Xi,Wang, Xiaofan,Yu, Zhenyang,Zhao, Bingyue,Zhao, Kang. "PhIO-Mediated oxidative dethioacetalization/dethioketalization under water-free conditions". . p. 48 - 65. Retrieved 2021/06/16.
• 2、 Farhadi, Saeid,Zaringhadam, Parisa,Sahamieh, Reza Zarei. "Photolytic decarboxylation of α-arylcarboxylic acids mediated by HgF2 under a dioxygen atmosphere". . p. 1965 - 1968. Retrieved 2007/10/03.