4-METHYL-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-METHYL-PIPERIDINE HYDROCHLORIDE
• CAS No.: 42796-28-1
• Molecular Formula: C6H13N
• Molecular Weight: 135.637
• Hs Code.: 2933399090
• Mol file: 42796-28-1.mol

Synonyms:4-METHYL-PIPERIDINE HYDROCHLORIDE;Nsc203095

Chemical Property of 4-METHYL-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 186-189.5 °C
• PSA: 12.03000
• LogP: 2.13670

Purity/Quality:

99% ^*data from raw suppliers

4-METHYLPIPERIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-METHYL-PIPERIDINE HYDROCHLORIDE

There total 6 articles about 4-METHYL-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

picoline (108-89-4) → 4-methyl-piperidine hydrochloride (42796-28-1)

Guidance literature:

picoline; With hydrogen; In water; at 160 ℃; for 24h; under 45004.5 Torr; Autoclave;

With hydrogenchloride;

DOI:10.1002/anie.201803426

Reference yield: 84.0%

4-methylpyridine-1-oxide (1003-67-4) → 4-methyl-piperidine hydrochloride (42796-28-1)

Guidance literature:

4-methylpyridine-1-oxide; With ammonium formate; 10percent palladium on carbon; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1021/jo015649g

Reference yield:

isoprene (78-79-5,9003-31-0) → 4-methyl-piperidine hydrochloride (42796-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂O; tetrahydrofuran / 72 h / 25 °C

2: 1.35 g / 1.) H₂, 2.) HCl / 1.) Pd(OH)2 / 1.) EtOH, 24 h, 2.) MeOH

With hydrogenchloride; hydrogen; palladium dihydroxide; In tetrahydrofuran; water;

upstream raw materials:

N-<(S)-α-Methoxycarbonylbenzyl>-4-methyl-3,4-didehydropiperidin

4-methylpyridine-1-oxide

isoprene

picoline

Downstream raw materials:

(4-methyl-piperidino)-phenyl-acetonitrile

(4-methylpiperidin-1-yl)(phenyl)methanone

2-(2-(3-(benzyloxy)phenyl)-5-methyl-7-(4-methylpiperidin-1-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetic acid

3-(4-methyl-piperidino)-1-(4-propoxy-phenyl)-propan-1-one; hydrochloride

Refernces

• 1、 Chen, Feng,Li, Wu,Sahoo, Basudev,Kreyenschulte, Carsten,Agostini, Giovanni,Lund, Henrik,Junge, Kathrin,Beller, Matthias. "Hydrogenation of Pyridines Using a Nitrogen-Modified Titania-Supported Cobalt Catalyst". supporting information. p. 14488 - 14492. Retrieved 2018/10/26.
• 2、 Zacharie,Moreau,Dockendorff. "A mild procedure for the reduction of pyridine N-oxides to piperidines using ammonium formate". . p. 5264 - 5265. Retrieved 2007/10/03.