3-Trimethylsilyl-2-oxazolidinone

Base Information

• Chemical Name: 3-Trimethylsilyl-2-oxazolidinone
• CAS No.: 43112-38-5
• Molecular Formula: C6H13 N O2 Si
• Molecular Weight: 159.26
• Hs Code.: 2934999090
• European Community (EC) Number: 256-098-2
• NSC Number: 617258
• DSSTox Substance ID: DTXSID00195703
• Nikkaji Number: J319.902I
• Wikidata: Q83068740
• Mol file: 43112-38-5.mol

Synonyms:3-Trimethylsilyl-2-oxazolidinone;43112-38-5;3-(Trimethylsilyl)oxazolidin-2-one;3-trimethylsilyl-1,3-oxazolidin-2-one;N-Trimethylsilyl-2-oxazolidinone;3-(Trimethylsilyl)-2-oxazolidinone;C6H13NO2Si;EINECS 256-098-2;3-(TRIMETHYLSILYL)-1,3-OXAZOLIDIN-2-ONE;NSC617258;SCHEMBL1950560;C6-H13-N-O2-Si;DTXSID00195703;MFCD00010197;AKOS015903524;Trimethyl(2-oxo-3-oxazolidinyl)silane;NSC-617258;2-Oxo-3-trimethylsilyl-1,3-oxazolidine;CS-0204861;T1535;3-(Trimethylsilyl)-2-oxazolidinone >=97.0%;D92482;3-(Trimethylsilyl)-2-oxazolidinone, >=97.0%

Chemical Property of 3-Trimethylsilyl-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 0.0434mmHg at 25°C
• Refractive Index: n20/D 1.455
• Boiling Point: 238°Cat760mmHg
• Flash Point: 76.7°C
• PSA: 29.54000
• Density: 1.02g/cm³
• LogP: 1.21140
• Storage Temp.: Freezer
• Sensitive.: Moisture Sensitive
• Water Solubility.: Hydrolyzes with water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.071555192
• Heavy Atom Count: 10
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Trimethylsilyl-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[Si](C)(C)N1CCOC1=O
• Uses: 3-Trimethylsilyl-2-oxazolidinone is used as salivating agent for silylation of carboxylic acids, 1,3-dicarbonyl compounds and hydroxyl compounds. It is also used as pharmaceutical intermediates.

Technology Process of 3-Trimethylsilyl-2-oxazolidinone

There total 4 articles about 3-Trimethylsilyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethylenecyclourethane (497-25-6) + chloro-trimethyl-silane (75-77-4) → 3-(trimethylsilyl)-2-oxazolidinone (43112-38-5)

Guidance literature:

With triethylamine; In butanone; at 20 ℃; for 1h;

DOI:10.1055/s-1981-29606

Reference yield: 90.0%

dimethylenecyclourethane (497-25-6) + trimethylsilyl trichloroacetate (25436-07-1) → 3-(trimethylsilyl)-2-oxazolidinone (43112-38-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 100 ℃;

DOI:10.1016/S0040-4039(00)98426-0

Reference yield:

→ 3-(trimethylsilyl)-2-oxazolidinone (43112-38-5) + 5-phenyl-3-triethylsilyl-2-oxazolidinone

Guidance literature:

upstream raw materials:

dimethylenecyclourethane

chloro-trimethyl-silane

trimethylsilyl trichloroacetate

Downstream raw materials:

Trimethylmethoxysilane

dimethylenecyclourethane

(crotonoyloxy)trimethylsilane

trimethylsilyl formate

Refernces

• 1、 Aizpurua, Jesus Mari,Palomo, Claudio. "Reagents and synthetic methods. 18 : N-trimethylsilyl-2-oxazolidinone, a useful silyating agent for hydroxy compounds". . p. 265 - 268. Retrieved 2007/10/02.
• 2、 -. "3-Alkylsilyl-2-oxazolidonone compounds and synthesis thereof". . . Retrieved 2008/06/13.