Bis(2,2,2-trifluoroethyl) phosphite

Base Information

• Chemical Name: Bis(2,2,2-trifluoroethyl) phosphite
• CAS No.: 92466-70-1
• Molecular Formula: C4H5 F6 O3 P
• Molecular Weight: 246.046
• Hs Code.: 2920909090
• European Community (EC) Number: 628-262-7
• Mol file: 92466-70-1.mol

Synonyms:92466-70-1;Bis(2,2,2-trifluoroethyl) phosphite;Bis(2,2,2-trifluoroethyl) Phosphonate;Phosphonic acid bis(2,2,2-trifluoroethyl) ester;oxo-bis(2,2,2-trifluoroethoxy)phosphanium;Phosphonic acid, bis(2,2,2-trifluoroethyl) ester;bis(trifluoroethyl)phosphonate;SCHEMBL672155;IMDCVAFSSZPRRM-UHFFFAOYSA-N;NYQKUVUXMIHXEA-UHFFFAOYSA-N;MFCD00063314;AKOS015856799;AS-10493;B2627;Bis(2,2,2-trifluoroethyl) phosphite, 97%;D88942;Bis(2,2,2-trifluoroethyl) phosphite, technical grade, 90%;1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxyphosphonoyloxy)ethane

Chemical Property of Bis(2,2,2-trifluoroethyl) phosphite

Chemical Property:

• Refractive Index: n20/D 1.332(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 59.00000
• Density: g/cm³
• LogP: 2.53390
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 244.98022496
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis(2,2,2-trifluoroethyl) Phosphite ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 23-26-28-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(F)(F)F)O[P+](=O)OCC(F)(F)F
• Uses: Bis(2,2,2-trifluoroethyl) phosphite was used in the synthesis of bis(2,2,2-trifluoroethyl phosphorochloridate. It was also employed as reagent for the synthesis of mono- and diesters of phosphorous acid.

Technology Process of Bis(2,2,2-trifluoroethyl) phosphite

There total 2 articles about Bis(2,2,2-trifluoroethyl) phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2,2-trifluoroethanol (75-89-8) → bis(2,2,2-trifluoroethyl)phosphite (92466-70-1)

Guidance literature:

With tert-butyl alcohol; phosphorus trichloride; In dichloromethane; for 15h;

DOI:10.1016/S0022-1139(01)00468-7

Reference yield: 82.0%

methyltrifluoromethyl ether (421-14-7) → bis(2,2,2-trifluoroethyl)phosphite (92466-70-1)

Guidance literature:

With tert-butyl alcohol; phosphorus trichloride; In dichloromethane; at 25 ℃; for 16h;

DOI:10.1055/s-1984-30856

Reference yield: 99.0%

N,N'-dibenzylidene-benzene-1,4-diamine (797-20-6) + bis(2,2,2-trifluoroethyl)phosphite (92466-70-1) → tetrakis(2,2,2-trifluoroethyl) {[1,4-phenylenebis(azanediyl)]bis(phenylmethylene)}bis(phosphonate)

Guidance literature:

In neat (no solvent); at 20 - 22 ℃; for 0.25h; Milling;

DOI:10.1055/s-0039-1691599

upstream raw materials:

2,2,2-trifluoroethanol

methyltrifluoromethyl ether

Downstream raw materials:

ethyl phenylacetate

C₂₄H₂₇F₆N₃O₁₀P₂

2,2,2-Trifluoroethyl phosphite cyclohexylammonium salt

C₃₂H₃₂F₃N₂O₈P

Refernces

• 1、 Belogorlova, N. A.,Bishimbayeva, G. K.,Chernysheva, N. A.,Gusarova, N. K.,Malysheva, S. F.,Nalibayeva, A. M.,Trofimov, B. A.,Verkhoturova, S. I.,Yasko, S. V.. "Synthesis of Amido- and Diamidophosphites with Polyfluoroalkyl Substituents". . p. 229 - 234. Retrieved 2020/04/17.
• 2、 Skoreński, Marcin,Oleksyszyn, Józef,Sieńczyk, Marcin. "Efficient methods for the synthesis of α-aminophosphonate fluoroalkyl esters". supporting information. p. 1566 - 1568. Retrieved 2013/03/28.