3,6-Dibromopyridazine

Base Information

• Chemical Name: 3,6-Dibromopyridazine
• CAS No.: 17973-86-3
• Molecular Formula: C4H2Br2N2
• Molecular Weight: 237.881
• Hs Code.: 29339900
• European Community (EC) Number: 687-847-5
• NSC Number: 66366
• DSSTox Substance ID: DTXSID70290072
• Nikkaji Number: J2.380.591J
• Wikidata: Q72464903
• Mol file: 17973-86-3.mol

Synonyms:3,6-dibromopyridazine;17973-86-3;3,6-Dibromopyridazide;Pyridazine, 3,6-dibromo-;MFCD00233947;3,6-dibromo-pyridazine;3,6-Dibromo pyridazine;NSC66366;NCIOpen2_003119;SCHEMBL610831;3,6-Dibromopyridazine, 97%;DTXSID70290072;VQAFMTSSCUETHA-UHFFFAOYSA-N;BCP19349;GEO-00969;NSC-66366;AKOS005259947;CS-W019835;PB10150;PS-4502;AC-25272;HY-59234;SY009350;AM20090061;BB 0259526;D5466;FT-0614752;EN300-87121;A853847;W-200176

Chemical Property of 3,6-Dibromopyridazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 116 °C
• Refractive Index: 1.616
• Boiling Point: 327.491 °C at 760 mmHg
• PKA: -1.18±0.10(Predicted)
• Flash Point: 151.862 °C
• PSA: 25.78000
• Density: 2.197 g/cm³
• LogP: 2.00160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 237.85642
• Heavy Atom Count: 8
• Complexity: 68.4

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dibromopyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36/37/39-22-37/39-36/37-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN=C1Br)Br
• Uses: 3,6-dibromopyridazine is an important intermediate in organic synthesis. It is mainly used in pharmaceutical intermediates, organic synthesis, organic solvents, and can also be used in dye production, pesticide production and perfumery.

Technology Process of 3,6-Dibromopyridazine

There total 9 articles about 3,6-Dibromopyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,6-dibromo-1,2,4,5-tetrazine (1071030-18-6) + calcium carbide (75-20-7) → 3,6-dibromopyridazine (17973-86-3)

Guidance literature:

With water; In 1,4-dioxane; at 100 ℃; for 120h; Sealed tube;

DOI:10.1002/asia.202100562

Reference yield: 50.0%

3,6-dihydroxypyridazine (123-33-1) → 3,6-dibromopyridazine (17973-86-3)

Guidance literature:

With phosphorus pentabromide; at 100 ℃;

DOI:10.1021/ol061711q

Reference yield: 50.0%

Maleic hydrazide (123-33-1) → 3,6-dibromopyridazine (17973-86-3)

Guidance literature:

With phosphorus pentabromide; for 2h;

DOI:10.1002/asia.201000737

upstream raw materials:

tetrahydropyridazine-3,6-dione

Maleic hydrazide

3,6-dihydroxypyridazine

3,6-bis(4-pyridyl)-1,2-diazine

Downstream raw materials:

3-metossi-6-bromopiridazina

4-amino-N-(6-bromo-pyridazin-3-yl)-benzenesulfonamide

6-bromopyridazin-3-amine

4-(6-bromo-pyridazin-3-yl)-1, 4-diazabicyclo [3.2. 2] nonane

Refernces

• 1、 Pedrali,Mantegani. "-". . p. 778. Retrieved 1958.
• 2、 Gao, Xiang-Jing,Zheng, He-Gen. "The difference in the CO2adsorption capacities of different functionalized pillar-layered metal-organic frameworks (MOFs)". supporting information. p. 9310 - 9316. Retrieved 2021/07/12.
• 3、 Happ, Bobby,Pavlov, Georges M.,Altuntas, Esra,Friebe, Christian,Hager, Martin D.,Winter, Andreas,Goerls, Helmar,Guenther, Wolfgang,Schubert, Ulrich S.. "Self-assembly of 3,6-bis(4-triazolyl)pyridazine ligands with copper(I) and silver(I) ions: Time-dependant 2D-NOESY and ultracentrifuge measurements". scheme or table. p. 873 - 880. Retrieved 2011/10/08.