(3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME

Base Information

• Chemical Name: (3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME
• CAS No.: 74396-78-4
• Molecular Formula: C9H5 F3 N2 O2
• Molecular Weight: 230.14
• Hs Code.: 2933990090
• Mol file: 74396-78-4.mol

Synonyms:(3Z)-7-(trifluoromethyl)-1H-indole-2,3-dione 3-oxime

Chemical Property of (3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME

Chemical Property:

• Vapor Pressure: 1.87E-05mmHg at 25°C
• Boiling Point: 324.8°C at 760 mmHg
• Flash Point: 150.2°C
• PSA: 61.69000
• Density: 1.66g/cm³
• LogP: 1.97380

Purity/Quality:

98%min ^*data from raw suppliers

3-(Hydroxyamino)-7-(trifluoromethyl)-2H-indol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME

There total 2 articles about (3Z)-7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE 3-OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide (444-93-9) → 7-Trifluoromethylisatin β-oxime (74396-78-4)

Guidance literature:

With tetrafluoroboric acid; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide; at 135 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2008.07.067

Reference yield:

7-trifluoromethylisatin (391-12-8) → 7-Trifluoromethylisatin β-oxime (74396-78-4)

Guidance literature:

7-trifluoromethylisatin; With hydroxylamine hydrochloride; In water; for 0.5h; Reflux;

With sodium acetate; In water; for 0.5h;

DOI:10.1021/acs.joc.6b02774

Reference yield: 98.0%

7-Trifluoromethylisatin β-oxime (74396-78-4) + phenylboronic acid (98-80-6) → (E)-N-[2-oxo-7-(trifluoromethyl)indolin-3-ylidene]aniline oxide

Guidance literature:

With pyridine; copper diacetate; In 1,2-dichloro-ethane; at 25 ℃;

DOI:10.1002/ejoc.201701324

upstream raw materials:

2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide

7-trifluoromethylisatin

Downstream raw materials:

2-amino-3-trifluoromethylbenzonitrile

Refernces

• 1、 Wu, Si-Yi,Ma, Xiao-Pan,Liang, Cui,Mo, Dong-Liang. "Synthesis of N-Aryl Oxindole Nitrones through a Metal-Free Selective N-Arylation Process". . p. 3232 - 3238. Retrieved 2017/03/23.