7-(Trifluoromethyl)indoline-2,3-dione

Base Information

• Chemical Name: 7-(Trifluoromethyl)indoline-2,3-dione
• CAS No.: 391-12-8
• Molecular Formula: C9H4F3NO2
• Molecular Weight: 215.131
• Hs Code.: 2933990090
• Mol file: 391-12-8.mol

Synonyms:Isatin,7-(trifluoromethyl)- (6CI);7-(Trifluoromethyl)isatin;

Chemical Property of 7-(Trifluoromethyl)indoline-2,3-dione

Chemical Property:

• Appearance/Colour: Brown solid
• Melting Point: 192-193 °C
• Refractive Index: 1.513
• PKA: 9.43±0.20(Predicted)
• PSA: 46.17000
• Density: 1.525 g/cm³
• LogP: 1.97820
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-(Trifluoromethyl)1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-(Trifluoromethyl)indoline-2,3-dione is an indole derivative as inhibitor of COX-1, COX-2, and ?catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease. An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer''s disease.

Technology Process of 7-(Trifluoromethyl)indoline-2,3-dione

There total 9 articles about 7-(Trifluoromethyl)indoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-[2-amino-3-(trifluoromethyl)phenyl]-2-(dimethyl-l4-sulfanylidene)-3-oxopropanenitrile → 7-trifluoromethylisatin (391-12-8)

Guidance literature:

With Oxone; In tetrahydrofuran; water; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1039/c3ob42024h

Reference yield: 78.0%

2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide (444-93-9) → 7-trifluoromethylisatin (391-12-8)

Guidance literature:

With sulfuric acid; at 60 - 80 ℃;

DOI:10.1016/j.cclet.2017.01.019

Reference yield: 61.0%

2-hydroxyimino-N-(2-trifluoromethyl-phenyl)-acetamide → 7-trifluoromethylisatin (391-12-8)

Guidance literature:

With sulfuric acid; at 55 - 80 ℃;

DOI:10.1021/jm0602256

upstream raw materials:

(E)-2-(hydroxyimino)-N-(2-(trifluoromethyl)phenyl)acetamide

2-(trifluoromethyl)benzenamine

dihydroxy-methyl-borane

5-iodo-7-(trifluoromethyl)indoline-2,3-dione

Downstream raw materials:

1-<2-chloro-3-(trifluoromethyl)phenyl>ethanone

2-chloro-3-trifluoromethylbenzamide

2-chloro-3-trifluoromethylbenzoic acid

2-chloro-3-(trifluoromethyl)benzylamine

Refernces

• 1、 Wu, Chang-Chun,Wang, Bao-Lei,Liu, Jing-Bo,Wei, Wei,Li, Yu-Xin,Liu, Yang,Chen, Ming-Gui,Xiong, Li-Xia,Yang, Na,Li, Zheng-Ming. "Design, synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors". . p. 1248 - 1251. Retrieved 2017/06/19.
• 2、 Myrianthopoulos, Vassilios,Kritsanida, Marina,Gaboriaud-Kolar, Nicolas,Magiatis, Prokopios,Ferandin, Yoan,Durieu, Emilie,Lozach, Olivier,Cappel, Daniel,Soundararajan, Meera,Filippakopoulos, Panagis,Sherman, Woody,Knapp, Stefan,Meijer, Laurent,Mikros, Emmanuel,Skaltsounis, Alexios-Leandros. "Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases". . p. 22 - 26. Retrieved 2013/03/13.