Technology Process of 10,13,16,19,22-Pentaoxa-7-azadispiro[5.1.12.2]docosane
There total 1 articles about 10,13,16,19,22-Pentaoxa-7-azadispiro[5.1.12.2]docosane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrochloric acid / H2O / 5 h / 55 °C
2: 3.32 g / NaHCO3 / H2O; dioxane / 4 h / 0 - 20 °C
3: 72 percent / TEMPO; NaHCO3; NaClO / H2O; acetonitrile / 20 °C
4: 99 percent / diethyl ether; CH2Cl2 / 0.25 h
5: 99 percent / H2 / 10 percent Pd/C / methanol
6: 73 percent / benzotriazol-1-yl-oxy-tripyrrolidinophosphonium PF6(1-); diisopropylethylamine / CH2Cl2 / 120 h / 20 °C
With
hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(02)01065-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrochloric acid / H2O / 5 h / 55 °C
2: 3.32 g / NaHCO3 / H2O; dioxane / 4 h / 0 - 20 °C
3: 72 percent / TEMPO; NaHCO3; NaClO / H2O; acetonitrile / 20 °C
4: 99 percent / diethyl ether; CH2Cl2 / 0.25 h
With
hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate;
In
1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(02)01065-7
